Department of Medical and Clinical Psychology, Tilburg University, Tilburg, the Netherlands.
Department of Psychology, Education and Child Studies, Erasmus University, Rotterdam, the Netherlands; Primary Care Unit School of Clinical Medicine, University of Cambridge, UK.
Psychoneuroendocrinology. 2019 Mar;101:182-185. doi: 10.1016/j.psyneuen.2018.11.015. Epub 2018 Nov 12.
Adverse childhood experiences have been shown to affect sensitivity to intranasal oxytocin administration, but the neural mechanisms underlying this altered sensitivity are unclear. The aim of the current study was to examine whether hippocampal abnormalities underlie the effects of adversity on the response to oxytocin administration. In a sample of healthy women (N = 54, age M = 19.63), we examined 1) the association between hippocampal volume and experiences of emotional maltreatment and 2) whether hippocampal volume reductions influence the effect of intranasal oxytocin administration on salivary oxytocin levels. There was no association between hippocampal volume and experiences of emotional maltreatment in the current study. However, we found that larger hippocampal volume was related to a stronger increase in salivary oxytocin level after intranasal oxytocin administration. The hippocampus may be a neural substrate underlying individual differences in sensitivity to oxytocin administration.
不良的童年经历已被证明会影响对鼻内催产素给药的敏感性，但这种敏感性改变的神经机制尚不清楚。本研究的目的是探讨海马异常是否是逆境对催产素给药反应的影响的基础。在一组健康女性（N=54，年龄 M=19.63）中，我们检查了 1）海马体积与情感虐待经历之间的关联，以及 2）海马体积减少是否会影响鼻内催产素给药对唾液催产素水平的影响。在本研究中，海马体积与情感虐待经历之间没有关联。然而，我们发现，更大的海马体积与鼻内催产素给药后唾液催产素水平的升高幅度更大有关。海马可能是个体对催产素给药敏感性差异的神经基础。
