Amiri Fatemeh, Neghab Masoud, Shouroki Fatemeh Kargar, Yousefinejad Saeed, Hassanzadeh Jafar
Student Research Committee, Shiraz University of Medical Sciences, Shiraz 71645-111, Iran.
Department of Occupational Health Engineering, Research Center for Health Sciences, Institute of Health, School of Health, Shiraz University of Medical Sciences, Shiraz 71645-111, Iran.
Toxics. 2018 Nov 21;6(4):70. doi: 10.3390/toxics6040070.
This study was undertaken to determine whether exposure of operating room personnel to inhalation anesthetics, nitrous oxide, isoflurane, and sevoflurane was associated with any hematological changes. This historical cohort study was performed in 2018 at a large public hospital in Shiraz, where 52 operating room personnel and 52 administrative staff were investigated. The blood sample was taken from all individuals for Complete Blood Count. Furthermore, demographic information was collected through questionnaires. Mean atmospheric concentrations of nitrous oxide, isoflurane, and sevoflurane, to which subjects were exposed, were 850.92, 2.40, and 0.18 ppm, respectively. The hematological parameters were within the normal range in both groups. However, the mean values of hemoglobin, hematocrit, mean corpuscular hemoglobin, mean corpuscular hemoglobin concentration, and red blood cell count in the exposed group were significantly lower than the control group. No significant differences were noted between the two groups as far as other hematological factors were concerned. These findings provide circumstantial evidence to further substantiate the notion that occupational exposure to inhalation anesthetics, under the exposure scenario explained in this study, is associated with subtle, subclinical, prepathologic hematological changes. Long-term consequence and ramifications of these effects require further investigation. The range of exposure levels to anesthetic gases in operating rooms.
本研究旨在确定手术室工作人员接触吸入性麻醉剂、氧化亚氮、异氟烷和七氟烷是否与任何血液学变化有关。这项历史性队列研究于2018年在设拉子的一家大型公立医院进行，对52名手术室工作人员和52名行政人员进行了调查。采集了所有人的血液样本进行全血细胞计数。此外，通过问卷调查收集了人口统计学信息。受试者接触的氧化亚氮、异氟烷和七氟烷的平均大气浓度分别为850.92、2.40和0.18 ppm。两组的血液学参数均在正常范围内。然而，接触组的血红蛋白、血细胞比容、平均红细胞血红蛋白、平均红细胞血红蛋白浓度和红细胞计数的平均值显著低于对照组。就其他血液学因素而言，两组之间未发现显著差异。这些发现提供了间接证据，进一步证实了在本研究所述的接触情况下，职业性接触吸入性麻醉剂与细微的、亚临床的、病理前血液学变化有关。这些影响的长期后果和影响需要进一步研究。手术室麻醉气体的接触水平范围。
