Department of Bioinformatics, Bharathiar University, Coimbatore, Tamil Nadu, India.
Department of Biomedical Science, Bharathidasan University, Tiruchirappalli, Tamil Nadu, India.
Nat Prod Res. 2020 Jun;34(11):1591-1596. doi: 10.1080/14786419.2018.1519819. Epub 2018 Nov 23.
Hydroxychavicol (HC), a major phenolic derivative isolated from the leaves of is well known for its antibacterial, antifungal and antimutagenic properties. The present study evaluated the antitumor activity of HC against Ehrlich Ascites Carcinoma (EAC) cells in Swiss albino mice and interaction of HC with the receptors involved in the cancer. Hydroxychavicol (200 and 400 mg/kg bw) was orally administered for 21 consecutive days and was effective in inhibiting the tumor growth in ascitic mouse model. HC consistently reduced the tumor volume, viable cell count, lipid peroxidation and elevated the life span of HC treated mice. Besides the hematological profiles, SGOT and SGPT levels reverted back to normal and oxidative stress markers GSH, SOD and CAT also increased in HC treated groups. docking analysis revealed that HC possessed potent antagonist activity against all the cancer targets demonstrating its inhibitory activity.
水芹醇（HC）是从水芹的叶子中分离出来的一种主要酚类衍生物，以其抗菌、抗真菌和抗诱变特性而闻名。本研究评估了 HC 对瑞士白化病小鼠艾氏腹水癌（EAC）细胞的抗肿瘤活性，以及 HC 与参与癌症的受体的相互作用。水芹醇（200 和 400mg/kg bw）连续口服 21 天，能有效抑制腹水小鼠模型中的肿瘤生长。HC 能持续减少肿瘤体积、活细胞计数、脂质过氧化，并延长 HC 治疗小鼠的寿命。除了血液学特征外，SGOT 和 SGPT 水平恢复正常，氧化应激标志物 GSH、SOD 和 CAT 在 HC 治疗组也增加。对接分析表明，HC 对所有癌症靶点均具有潜在的拮抗剂活性，表现出其抑制活性。
