Department of Pharmaceutical Technology, Jadavpur University, Kolkata, India.
Pharm Biol. 2010 Dec;48(12):1337-43. doi: 10.3109/13880201003792592.
Sansevieria roxburghiana Schult. & Schult. f. (Agavaceae) is a herbaceous perennial plant traditionally used for coughs, rheumatism; as an expectorant, febrifuge, purgative, and tonic.
To evaluate the hydroalcoholic extract of S. roxburghiana rhizome (HASR) for antitumor activity against Ehrlich ascites carcinoma (EAC) in Swiss albino mice.
Twenty-Four hours after intraperitoneal inoculation of tumor (EAC) cells in mice, HASR was administered at 50 and 100 mg/kg body weight for nine consecutive days. On day 10 half of the mice were sacrificed and rest were kept alive for assessment of increase in life-span. The antitumor effect of HASR was assessed by evaluating tumor volume, packed cell count, viable and non-viable tumor cell count, median survival time and increase in life-span of EAC bearing hosts. Hematological profiles and serum biochemical parameters were estimated. Further, antioxidant properties were assessed by estimating lipid peroxidation, reduced glutathione (GSH), superoxide dismutase (SOD) and catalase (CAT).
HASR showed a significant (p < 0.001) decrease in tumor volume, packed cell volume and viable cell count and increased the life span of EAC bearing mice. Hematological and serum biochemical profiles were restored to normal levels in HASR treated mice as compared to EAC control. HASR treatment significantly (p <0.001) decreased lipid peroxidation and recovered GSH, SOD and CAT towards normal as compared to EAC control.
The present study demonstrates that S. roxburghiana rhizome exhibited remarkable antitumor activity in Swiss mice that is plausibly attributable to its augmenting endogenous antioxidant mechanisms.
蛇尾兰（Agavaceae）是一种多年生草本植物，传统上用于治疗咳嗽、风湿；作为祛痰剂、退烧药、泻药和滋补剂。
评估蛇尾兰根茎的水醇提取物（HASR）对瑞士白化小鼠艾氏腹水癌（EAC）的抗肿瘤活性。
在小鼠腹腔接种肿瘤（EAC）细胞 24 小时后，连续 9 天给予 HASR50 和 100mg/kg 体重。第 10 天，一半小鼠被处死，其余小鼠存活以评估寿命延长。通过评估肿瘤体积、红细胞压积、活肿瘤细胞和死肿瘤细胞计数、中位生存时间和 EAC 宿主的寿命延长，评估 HASR 的抗肿瘤作用。评估血液学参数和血清生化参数。进一步通过评估脂质过氧化、还原型谷胱甘肽（GSH）、超氧化物歧化酶（SOD）和过氧化氢酶（CAT）来评估抗氧化性能。
HASR 显著（p<0.001）降低了肿瘤体积、红细胞压积和活细胞计数，并延长了 EAC 荷瘤小鼠的寿命。与 EAC 对照组相比，HASR 治疗的小鼠血液学和血清生化参数恢复正常水平。与 EAC 对照组相比，HASR 治疗显著（p<0.001）降低了脂质过氧化作用，并恢复了 GSH、SOD 和 CAT 至正常水平。
本研究表明，蛇尾兰根茎在瑞士小鼠中表现出显著的抗肿瘤活性，这可能归因于其增强内源性抗氧化机制。
