Zhao Shankun, Wang Jiamin, Xie Qiang, Liu Yangzhou, Luo Lianmin, Zhu Zhiguo, Li Ermao, Zhao Zhigang
Department of Urology & Andrology, Minimally Invasive Surgery Center, Guangdong Provincial Key Laboratory of Urology, The First Affiliated Hospital of Guangzhou Medical University. Guangzhou, Guangdong, China.
Department of Reproduction, Southern Medical University Affiliate Dongguan People's Hospital, Dongguan, 523059, China.
Int J Impot Res. 2019 Mar;31(2):74-84. doi: 10.1038/s41443-018-0093-8. Epub 2018 Nov 23.
Psoriasis is a common skin disease with the global prevalence of about 2%. Mounting evidence has emerged indicating that there was an association between psoriasis and increased susceptibility to erectile dysfunction (ED). We aimed to assess whether psoriasis was a risk factor for ED through a comprehensive literature review and meta-analysis. The MEDLINE (PubMed), EMBASE, and the Cochrane Library were systematically searched for all studies investigating the erectile function in psoriatic patients. The association between psoriasis and risk of ED was summarized using the odds ratios (OR) with a 95% confidence interval (CI). The protocol for this meta-analysis is available from PROSPERO (CRD42018093025). Overall, 1829449 participants (the mean age ranged from 44 years to 56.3 years) were included from 8 studies (6 cross-sectional, 1 cohort, and 1 case-control study); 39490 of whom were patients with psoriasis, with the mean disease duration from 6 months to 19.9 years. The methodological quality of the 8 included studies was considered to be either moderate or high quality. Synthesis results from the included studies revealed that psoriasis was significantly associated with an increased risk of ED in psoriatic patients (OR = 1.62, 95%CI: 1.37-1.91, P < 0.001; heterogeneity: I = 62.6%, P = 0.009). The results were consistent after multivariable adjustment (6 studies; combined OR = 1.5, 95%CI: 1.31-1.72, P < 0.001; heterogeneity: I = 53.5%, P = 0.056). Evidence from this meta-analysis indicates that patients with psoriasis have a significantly elevated risk of ED.
银屑病是一种常见的皮肤病，全球患病率约为2%。越来越多的证据表明，银屑病与勃起功能障碍（ED）易感性增加之间存在关联。我们旨在通过全面的文献综述和荟萃分析来评估银屑病是否为ED的危险因素。系统检索了MEDLINE（PubMed）、EMBASE和Cochrane图书馆中所有调查银屑病患者勃起功能的研究。使用优势比（OR）及95%置信区间（CI）总结银屑病与ED风险之间的关联。该荟萃分析的方案可从PROSPERO（CRD42018093025）获取。总体而言，8项研究（6项横断面研究、1项队列研究和1项病例对照研究）纳入了1829449名参与者（平均年龄在44岁至56.3岁之间）；其中39490名是银屑病患者，平均病程为6个月至19.9年。纳入的8项研究的方法学质量被认为是中等或高质量。纳入研究的综合结果显示，银屑病与银屑病患者ED风险增加显著相关（OR = 1.62，95%CI：1.37 - 1.91，P < 0.001；异质性：I² = 62.6%，P = 0.009）。多变量调整后结果一致（6项研究；合并OR = 1.5，95%CI：1.31 - 1.72，P < 0.001；异质性：I² = 53.5%，P = 0.056）。该荟萃分析的证据表明，银屑病患者患ED的风险显著升高。
