Linares-Gonzalez Laura, Lozano-Lozano Ignacio, Gutierrez-Rojas Luis, Lozano-Lozano Mario, Rodenas-Herranz Teresa, Ruiz-Villaverde Ricardo
Department of Dermatology, Hospital Universitario San Cecilio, 18016 Granada, Spain.
Biohealth Research Institute in Granada (ibs.GRANADA), 18012 Granada, Spain.
Life (Basel). 2021 Nov 29;11(12):1314. doi: 10.3390/life11121314.
Atopic dermatitis (AD) is a chronic inflammatory disease of the skin whose main symptom is pruritus and may affect all age ranges. Regarding the prevalence, it has been estimated at around 10% of the world population. Many concomitant diseases have been associated with AD, but the causal relationship between AD and psychological impairment has not been clearly established. Scientific literature studying the probable association between male or female sexual dysfunction and dermatological pathology is limited, even more so in AD. This systematic review was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) reporting guidelines and the Cochrane Collaboration methodology for systematic reviews. All relevant articles in English were identified through a search from inception to 10 December 2020, including the following databases: Medline (via PubMed), Scopus, Web of Science Core Collection, and SciELO. The results of the search were compiled using the COVIDENCE software for systematic reviews. The methodological quality of the included studies was done using the "Quality Assessment Tool for Observational Cohort and Cross-Sectional Studies" and the "Quality Assessment of Case-Control Studies" developed by the National Heart, Lung, and Blood Institute, National Institutes of Health (NIH). Our search yielded potentially relevant studies. Five studies that evaluated the prevalence of sexual dysfunction in atopic dermatitis were retrieved after applying the selection criteria. The present systematic review achieved data from 8088 patients with atopic dermatitis from four articles. Sample sizes for atopic dermatitis patients ranged from 266 to 3997. We identified one cohort study with four years of follow-up, three studies with a cross-sectional design, and one case-control study. Three studies reported data disaggregated by the severity of atopic dermatitis. Two studies included healthy controls with a total sample size of 1,747,755 subjects. Two studies compared data with other dermatological conditions such as psoriasis. In conclusion, we can establish that unlike other psychological comorbidities such as anxiety and depression, sexual dysfunction is a field scarcely explored in the literature. This sexual dysfunction focuses on the male sex in large population studies and in clinical diagnoses without exploring it through specific and validated questionnaires in this regard. Further studies focused on both genders are needed. It is important to correlate this sexual dysfunction with the severity of the disease, previous treatments, and cardiovascular comorbidities.
特应性皮炎（AD）是一种慢性皮肤炎症性疾病，其主要症状为瘙痒，可影响所有年龄段。关于患病率，据估计约占世界人口的10%。许多伴发疾病与AD相关，但AD与心理障碍之间的因果关系尚未明确确立。研究男性或女性性功能障碍与皮肤病学病理之间可能关联的科学文献有限，在AD方面更是如此。本系统评价遵循系统评价和Meta分析的首选报告项目（PRISMA）报告指南以及Cochrane协作网系统评价方法进行。通过从创刊至2020年12月10日进行检索，识别了所有英文相关文章，包括以下数据库：Medline（通过PubMed）、Scopus、科学引文索引核心合集和科学电子图书馆在线（SciELO）。检索结果使用COVIDENCE软件进行系统评价整理。纳入研究的方法学质量使用美国国立卫生研究院（NIH）国家心肺血液研究所开发的“观察性队列和横断面研究质量评估工具”以及“病例对照研究质量评估”进行评估。我们的检索产生了潜在相关研究。应用选择标准后，检索到五项评估特应性皮炎中性功能障碍患病率的研究。本系统评价从四篇文章中获取了8088例特应性皮炎患者的数据。特应性皮炎患者的样本量从266到3997不等。我们确定了一项随访四年的队列研究、三项横断面设计研究和一项病例对照研究。三项研究报告了按特应性皮炎严重程度分类的数据。两项研究纳入了健康对照，总样本量为1,747,755名受试者。两项研究将数据与其他皮肤病如银屑病进行了比较。总之，我们可以确定，与焦虑和抑郁等其他心理共病不同，性功能障碍是文献中很少探索的领域。在大规模人群研究和临床诊断中，这种性功能障碍主要关注男性，而未通过这方面特定且经过验证的问卷进行探究。需要针对两性开展进一步研究。将这种性功能障碍与疾病严重程度、既往治疗以及心血管共病相关联很重要。
