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氨基端基化超支化聚合物修饰的还原氧化石墨烯光热/ pH双响应药物递送系统及其对肿瘤细胞的化学-光热疗法

Photothermal/pH Dual-Responsive Drug Delivery System of Amino-Terminated HBP-Modified rGO and the Chemo-Photothermal Therapy on Tumor Cells.

作者信息

Zhang Wei, Dai Jiamu, Zhang Guangyu, Zhang Yu, Li Suying, Nie Du

机构信息

National and Local Joint Engineering Research Center of Technical Fiber Composites for Safety and Protection, Nantong University, Nantong, 226019, China.

School of Textile and Clothing, Nantong University, Nantong, 226019, China.

出版信息

Nanoscale Res Lett. 2018 Nov 23;13(1):379. doi: 10.1186/s11671-018-2787-8.

DOI:10.1186/s11671-018-2787-8
PMID:30470923
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6251798/
Abstract

In this paper, a simple method to prepare hydrophilic reduced graphene oxide (rGO) was proposed via reducing GO by amino-terminated hyperbranched polymer (NHBP), the as-prepared NrGO could present excellent dispersibility, near infrared (NIR) light absorbance, photothermal conversion ability and stability. Then, the doxorubicin hydrochloride (DOX) was conjugated with NrGO to prepare the drug-loading system, and a pH/photothermal dual-responsive drug delivery behavior was characterized. At acidic environment or under NIR laser irradiation, the drug release rate could be improved, which is beneficial to control release anti-tumor drug in tumor tissues. What is more, the in vitro cell experiments revealed that NrGO was well biocompatible, and in the tumor inhibition part, comparing to the control group without any treatment, DOX@NrGO gained efficient chemo-photothermal synergetic therapy, the inhibition rate of which was much higher than single chemotherapy of released DOX. Therefore, the as-prepared DOX@NrGO obtained great potential application in tumor therapy and an excellent candidate in other biomed applications.

摘要

本文提出了一种通过氨基封端的超支化聚合物（NHBP）还原氧化石墨烯（GO）来制备亲水性还原氧化石墨烯（rGO）的简单方法，所制备的NrGO具有优异的分散性、近红外（NIR）光吸收能力、光热转换能力和稳定性。然后，将盐酸阿霉素（DOX）与NrGO偶联制备载药系统，并对其pH/光热双响应药物递送行为进行了表征。在酸性环境或近红外激光照射下，药物释放速率可提高，这有利于在肿瘤组织中控制抗肿瘤药物的释放。此外，体外细胞实验表明NrGO具有良好的生物相容性，在肿瘤抑制方面，与未进行任何处理的对照组相比，DOX@NrGO获得了高效的化学-光热协同治疗，其抑制率远高于游离DOX的单一化疗。因此，所制备的DOX@NrGO在肿瘤治疗中具有巨大的潜在应用价值，是其他生物医学应用中的优秀候选者。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c733/6251798/43a165b8de5b/11671_2018_2787_Fig12_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c733/6251798/ea0199f3623c/11671_2018_2787_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c733/6251798/af69f9872dd1/11671_2018_2787_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c733/6251798/5e72bce0cd2b/11671_2018_2787_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c733/6251798/1794951a5dd7/11671_2018_2787_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c733/6251798/0ec22c06fc1f/11671_2018_2787_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c733/6251798/b7b888f2106c/11671_2018_2787_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c733/6251798/2e61dbacdd64/11671_2018_2787_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c733/6251798/aad22257deee/11671_2018_2787_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c733/6251798/6580e37fe5a9/11671_2018_2787_Fig9_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c733/6251798/2ff416eb4ffa/11671_2018_2787_Fig10_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c733/6251798/4a34f1b228fa/11671_2018_2787_Fig11_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c733/6251798/43a165b8de5b/11671_2018_2787_Fig12_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c733/6251798/ea0199f3623c/11671_2018_2787_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c733/6251798/af69f9872dd1/11671_2018_2787_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c733/6251798/5e72bce0cd2b/11671_2018_2787_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c733/6251798/1794951a5dd7/11671_2018_2787_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c733/6251798/0ec22c06fc1f/11671_2018_2787_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c733/6251798/b7b888f2106c/11671_2018_2787_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c733/6251798/2e61dbacdd64/11671_2018_2787_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c733/6251798/aad22257deee/11671_2018_2787_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c733/6251798/6580e37fe5a9/11671_2018_2787_Fig9_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c733/6251798/2ff416eb4ffa/11671_2018_2787_Fig10_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c733/6251798/4a34f1b228fa/11671_2018_2787_Fig11_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c733/6251798/43a165b8de5b/11671_2018_2787_Fig12_HTML.jpg

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3
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