Colizzi Marco, Bhattacharyya Sagnik
Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom.
Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom.
Prog Brain Res. 2018;242:179-216. doi: 10.1016/bs.pbr.2018.08.010. Epub 2018 Oct 20.
The following chapter offers an overview of results of experimental studies conducted among healthy individuals examining the effects of acute administration of Δ9-THC and other cannabinoids, alone or in combination, on brain function and behavior, also as a function of previous cannabis exposure. In light of their methodological design, these studies have advanced the understanding of the neurobiological mechanisms increasing the risk of long-lasting cognitive dysfunction as well as psychosis in regular cannabis users. Also, direct and indirect evidence supports an alteration of different neurotransmitters, such as dopamine, glutamate, and gamma-aminobutyric acid, in modulating the manifestation of neurocognitive dysfunction and psychosis in the context of both acute and chronic cannabis exposure. Future multimodal neuroimaging studies will integrate the longitudinal information to track the long-term changes in brain neurochemistry and neurophysiology as well as other potential biomarkers induced by sustained cannabis use.
以下章节概述了在健康个体中进行的实验研究结果，这些研究考察了单独或联合急性给予Δ9-四氢大麻酚（Δ9-THC）和其他大麻素对脑功能和行为的影响，同时也考察了既往大麻暴露情况的作用。鉴于其方法学设计，这些研究增进了我们对神经生物学机制的理解，这些机制增加了长期大麻使用者出现持久认知功能障碍以及精神病的风险。此外，直接和间接证据支持在急性和慢性大麻暴露背景下，多巴胺、谷氨酸和γ-氨基丁酸等不同神经递质的改变在调节神经认知功能障碍和精神病表现方面的作用。未来的多模态神经影像学研究将整合纵向信息，以追踪长期大麻使用引起的脑神经化学和神经生理学以及其他潜在生物标志物的长期变化。
