Department of Rehabilitation Medicine, Keio University School of Medicine, Tokyo, Japan.
Department of Rehabilitation Medicine, Keio University School of Medicine, Tokyo, Japan; Saiseikai Kanagawaken Hospital, Yokohama, Kanagawa, Japan.
Cortex. 2019 Oct;119:594-605. doi: 10.1016/j.cortex.2018.10.018. Epub 2018 Oct 31.
Unilateral spatial neglect (USN) can be defined as a failure to orient to contra-lesional stimuli in the absence of either sensory or motor defects. Although the behavioral and clinical effects of prism adaptation (PA) are widely accepted, its underlying mechanisms are still controversial. However, recent neuroimaging and neurophysiological studies support the idea that PA affects the visual attention and sensorimotor networks including in the parietal cortex and cerebellum. We investigate the effect of PA on functional connectivity (FC) in attention and sensorimotor networks, evaluating changes of resting-state FC before and after PA in healthy individuals using functional magnetic resonance imaging (fMRI). MR sessions were conducted before PA, after PA (Post1), and 1 h after PA (Post2). The FC between the right frontal eye (FEF) field and the right intraparietal sulcus was significantly decreased at Post1 and that between the right FEF and the right anterior cingulate cortex was significantly increased after PA and recovered within 1 h. This is the first study to demonstrate transient changes of resting-state FC in the right dorsal attention network (DAN) by PA in healthy adults using fMRI. These results will contribute to the elucidation of the underling mechanism of PA therapy and to devising new therapies for USN and/or other higher cortical dysfunctions.
单侧空间忽略症（USN）可定义为在不存在感觉或运动缺陷的情况下，对病变对侧刺激的定向障碍。尽管棱镜适应（PA）的行为和临床效果已被广泛接受，但它的潜在机制仍存在争议。然而，最近的神经影像学和神经生理学研究支持这样一种观点，即 PA 会影响视觉注意力和感觉运动网络，包括顶叶皮层和小脑。我们使用功能磁共振成像（fMRI）研究了 PA 对注意力和感觉运动网络功能连接（FC）的影响，评估了健康个体在 PA 前后静息状态 FC 的变化。MR 会话在 PA 之前、PA 后（Post1）和 PA 后 1 小时（Post2）进行。在 Post1 时，右侧额眼（FEF）区与右侧顶内沟之间的 FC 显著降低，而在 PA 后，右侧 FEF 与右侧前扣带皮质之间的 FC 显著增加，并在 1 小时内恢复。这是第一项使用 fMRI 研究 PA 对健康成年人右侧背侧注意网络（DAN）静息状态 FC 的瞬时变化的研究。这些结果将有助于阐明 PA 治疗的潜在机制，并为 USN 和/或其他高级皮质功能障碍设计新的治疗方法。
