Department of Epidemiology and Biostatistics, College of Public Health, University of Georgia, University of Georgia Health Sciences Campus, Athens, GA.
Transfus Med Rev. 2019 Jan;33(1):35-42. doi: 10.1016/j.tmrv.2018.10.001. Epub 2018 Oct 31.
The presence of antibodies to Zika virus (ZIKV) and dengue virus (DENV) can be detected in blood donations. Donation-based surveillance provides an alternative strategy to estimate population prevalence by detecting antibodies that are circulating. To estimate population prevalence, we conducted a systematic review of literature on the seroprevalence of ZIKV and DENV antibodies in blood donations. We searched PubMed and Web of Science for studies that reported the seroprevalence of ZIKV and DENV in blood donations. The title and abstract of each study were screened by 2 reviewers simultaneously for possible inclusion, and the full text of selected studies was reviewed to ensure that they met inclusion criteria (used primary data collection, reported evidence of immunoglobulin M (IgM) or immunoglobulin G (IgG) antibodies in the blood supply, and included a representative sample of the total population). Immunoglobin test measuring levels of antibodies to IgM and IgG and number of positive cases were extracted from each study. No exclusions were made based on language or country. Our initial search identified 1890 studies after excluding duplicates, of which 76 were assessed for full text eligibility to ensure that they met our final inclusion criteria. There were 14 studies included in our review; 11 examined the seroprevalence of DENV, and 3 examined ZIKV. The highest seroprevalence by IgM was 2.82% for DENV and 0.53% for ZIKV. Our results indicate that the seroprevalence of ZIKV and DENV antibody presence in countries with active transmission is higher than reports by traditional surveillance in some countries. This finding is expected due to the large percentage of asymptomatic cases. The highest seroprevalence was observed for IgG, which can persist over long periods of time compared to IgM. Screening of blood donations may help supplement traditional surveillance measures, especially during outbreak settings.
血液中可检测到寨卡病毒 (ZIKV) 和登革热病毒 (DENV) 的抗体。基于献血的监测是通过检测循环抗体来估计人群流行率的替代策略。为了估计人群流行率，我们对血液中寨卡病毒和登革热病毒抗体的血清流行率进行了系统评价。我们在 PubMed 和 Web of Science 上搜索了报告血液中寨卡病毒和登革热病毒血清流行率的研究。由 2 位审查员同时筛选每篇研究的标题和摘要，以确定其是否可能被纳入，然后对选定研究的全文进行审查，以确保其符合纳入标准（使用了原始数据收集、报告了血液供应中免疫球蛋白 M (IgM) 或免疫球蛋白 G (IgG) 抗体的证据，并包括了总人群的代表性样本）。从每项研究中提取了用于测量 IgM 和 IgG 抗体水平和阳性病例数的免疫球蛋白检测结果。我们没有基于语言或国家进行排除。在排除重复项后，我们最初的搜索确定了 1890 项研究，其中有 76 项研究进行了全文资格评估，以确保符合我们的最终纳入标准。共有 14 项研究被纳入综述；11 项研究检测了 DENV 的血清流行率，3 项研究检测了 ZIKV。IgM 的最高血清流行率为 2.82%，DENV 为 0.53%，ZIKV 为 0.53%。我们的结果表明，在有病毒传播的国家，寨卡病毒和登革热病毒抗体存在的血清流行率高于一些国家传统监测的报告。由于无症状病例的比例较高，这种情况是可以预期的。最高的血清流行率是 IgG，它比 IgM 更能长期存在。对献血的筛查可能有助于补充传统的监测措施，尤其是在疫情期间。
