Abd El-Wahab Ekram W, Elfiky Karima S R, Ghanem Mohamed A, Shatat Hanan Z
Tropical Health Department, High Institute of Public Health, Alexandria University, 21561, Alexandria, Egypt.
Fellow of Tropical Health Department, High Institute of Public Health, Alexandria University, 21561, Alexandria, Egypt.
J Virus Erad. 2022 Jun 27;8(2):100077. doi: 10.1016/j.jve.2022.100077. eCollection 2022 Jun.
The risk of transfusion transmitted dengue (DENV) is increasingly recognized and poses a risk to blood safety as well as spreading into non-immune communities.
To determine dengue serological profile, environmental risk, knowledge, and preventive measures among blood donors in a national blood bank in northern Egypt.
A total of 500 blood donors were enrolled into this study between June and September 2018. Socio-demographic and medical data were collected using a predesigned questionnaire. Blood samples were screened for anti-DENV IgM, anti-DENV IgG and non-structural protein 1 antigen (DENV-NS1 antigen).
History of past dengue exposure was identified in 10.2% of blood donors. No samples (0.0%) tested positive for anti-DENV IgG, IgM or NS1 antigen. At the time of blood donation, no individuals had any symptoms suggestive of a dengue-related illness. Dengue exposure strongly correlated with travel to the Kingdom of Saudi Arabia (KSA), Sudan and the El-Quseir outbreak area in Egypt. Knowledge of dengue and prevention methods was found to be substantially deficient, and the relatively higher level of knowledge among exposed donors did not translate into appropriate preventative measures.
Our risk assessment shows the impact of travel on DENV exposure and highlights its potential threat to disease spread in Egypt. Dengue awareness programs are urgently needed for effective prevention of transmission.
输血传播登革热（DENV）的风险日益受到认可，对血液安全构成风险，并可能传播到非免疫社区。
确定埃及北部一家国家血库中献血者的登革热血清学特征、环境风险、知识水平和预防措施。
2018年6月至9月期间，共有500名献血者纳入本研究。使用预先设计的问卷收集社会人口统计学和医学数据。对血样进行抗DENV IgM、抗DENV IgG和非结构蛋白1抗原（DENV-NS1抗原）筛查。
10.2%的献血者有既往登革热暴露史。没有样本（0.0%）抗DENV IgG、IgM或NS1抗原检测呈阳性。献血时，没有个体有任何提示登革热相关疾病的症状。登革热暴露与前往沙特阿拉伯王国（KSA）、苏丹和埃及库赛尔疫情爆发地区的旅行密切相关。发现对登革热和预防方法的了解严重不足，暴露献血者中相对较高的知识水平并未转化为适当的预防措施。
我们的风险评估显示了旅行对DENV暴露的影响，并突出了其对埃及疾病传播的潜在威胁。迫切需要开展登革热意识项目以有效预防传播。
