Department of Food Science and Human Nutrition, University of Illinois, Urbana-Champaign, Urbana, IL, USA. Electronic address: https://twitter.com/@eylemkul.
School of Kinesiology and Community Health, University of Illinois, Urbana-Champaign, Urbana, IL, USA.
Trends Endocrinol Metab. 2019 Jan;30(1):25-38. doi: 10.1016/j.tem.2018.10.006. Epub 2018 Nov 22.
Estrogens and estrogen receptors (ERs) regulate metabolism in both normal physiology and in disease. The metabolic characteristics of intrinsic breast cancer subtypes change based on their ER expression. Crosstalk between estrogen signaling elements and several key metabolic regulators alters metabolism in breast cancer cells, and enables tumors to rewire their metabolism to adapt to poor perfusion, transient nutrient deprivation, and increased acidity. This leads to the selection of drug-resistant and metastatic clones. In this review we discuss studies revealing the role of estrogen signaling elements in drug resistance development and metabolic adaptation during breast cancer progression.
雌激素和雌激素受体（ER）在正常生理和疾病中调节代谢。内在乳腺癌亚型的代谢特征根据其 ER 表达而改变。雌激素信号元件与几个关键代谢调节剂之间的串扰改变了乳腺癌细胞的代谢，使肿瘤能够重新布线其代谢以适应灌注不良、短暂的营养剥夺和酸度增加。这导致了耐药和转移性克隆的选择。在这篇综述中，我们讨论了揭示雌激素信号元件在乳腺癌进展过程中耐药性发展和代谢适应中的作用的研究。
