Weller M, Heimann K, Wiedemann P
Département de Chirurgie vitréo-rétinienne, Université de Cologne, R.F.A.
J Fr Ophtalmol. 1988;11(3):243-7.
Proliferative vitreoretinopathy (PVR) is characterized by the periretinal proliferation of nonneoplastic cells complicated by traction retinal detachment. In this study, we report the demonstration of macrophages, which are thought to be involved in the etiology of this intraocular disease, in human periretinal membranes by an immunochemical staining procedure using a monoclonal anti-human macrophage antibody. Fibronectin, a high-molecular protein of plasma and extracellular matrix, may be visualized accordingly and could act concomitantly with macrophages as an important factor in PVR. Fibronectin is shown to be present in high quantities (Elisa) in vitreous aspirates from patients with PVR. We hypothesize that the interaction of macrophages and fibronectin may be a crucial step in the development of PVR.
增殖性玻璃体视网膜病变（PVR）的特征是视网膜外非肿瘤性细胞增殖，并伴有牵引性视网膜脱离。在本研究中，我们报告了通过使用单克隆抗人巨噬细胞抗体的免疫化学染色程序，在人视网膜外膜中证实了巨噬细胞，据认为巨噬细胞参与了这种眼内疾病的病因。纤连蛋白是血浆和细胞外基质中的一种高分子蛋白质，因此可以被观察到，并且可能与巨噬细胞一起作为PVR的一个重要因素发挥作用。已证明PVR患者的玻璃体吸出物中含有大量纤连蛋白（酶联免疫吸附测定法）。我们推测巨噬细胞与纤连蛋白的相互作用可能是PVR发生发展中的关键步骤。
