Cancer Research @ UCC, Western Gateway Building, University College Cork, Western Road, Cork, Ireland.
Cancer Research @ UCC, Western Gateway Building, University College Cork, Western Road, Cork, Ireland.
Cancer Lett. 2019 Feb 1;442:475-482. doi: 10.1016/j.canlet.2018.11.015. Epub 2018 Nov 22.
Electrochemotherapy is an emerging treatment modality for cancer patients which can effectively reduce tumour burden and induce immunogenic cell death. Electrochemotherapy is most commonly used with bleomycin as the drug of choice, here we examine the efficacy of electrochemotherapy with cisplatin. Electrochemotherapy with cisplatin was found to effectively reduce tumour growth in a range of murine models and induce significant intratumoural recruitment of myeloid and humoral immune cells. Following the observations of immune system mobilisation, we have shown an ability of electrochemotherapy to reduce metastatic potential as determined by tumour burden in the lung, and to exert an abscopal effect by reducing growth at distal untreated secondary tumours.
电化学疗法是一种新兴的癌症治疗方法，可有效减轻肿瘤负担并诱导免疫原性细胞死亡。电化学疗法最常与博来霉素联合使用，我们在此检查了顺铂电化学疗法的疗效。顺铂电化学疗法可有效抑制多种小鼠模型中的肿瘤生长，并诱导肿瘤内髓样和体液免疫细胞的大量募集。在观察到免疫系统的动员作用后，我们发现电化学疗法具有降低肿瘤肺转移潜能的能力，并且通过减少未治疗的远端继发肿瘤的生长来发挥远隔效应。
