Department of Physiology, University of Tennessee Health Science Center, 71 S. Manassas Street Memphis, Memphis, TN 38163, USA.
Department of Physiology, University of Tennessee Health Science Center, 71 S. Manassas Street Memphis, Memphis, TN 38163, USA.
Prog Lipid Res. 2019 Jan;73:28-45. doi: 10.1016/j.plipres.2018.11.001. Epub 2018 Nov 22.
12/15-lipoxygenase (12/15-LOX) is an enzyme, which oxidizes polyunsaturated fatty acids, particularly omega-6 and -3 fatty acids, to generate a number of bioactive lipid metabolites. A large number of studies have revealed the importance of 12/15-LOX role in oxidative and inflammatory responses. The in vitro studies have demonstrated the ability of 12/15-LOX metabolites in the expression of various genes and production of cytokine related to inflammation and resolution of inflammation. The studies with the use of knockout and transgenic animals for 12/15-LOX have further shown its involvement in the pathogenesis of a variety of human diseases, including cardiovascular, renal, neurological and metabolic disorders. This review summarizes our current knowledge on the role of 12/15-LOX in inflammation and various human diseases.
12/15-脂氧合酶（12/15-LOX）是一种酶，可氧化多不饱和脂肪酸，特别是 ω-6 和 ω-3 脂肪酸，生成多种生物活性脂质代谢物。大量研究表明 12/15-LOX 在氧化和炎症反应中的作用很重要。体外研究已经证明了 12/15-LOX 代谢物在各种基因表达和细胞因子产生中的作用，这些细胞因子与炎症和炎症消退有关。使用 12/15-LOX 基因敲除和转基因动物的研究进一步表明，它参与了多种人类疾病的发病机制，包括心血管、肾脏、神经和代谢紊乱。这篇综述总结了我们目前对 12/15-LOX 在炎症和各种人类疾病中的作用的认识。
