University of California, San Diego/San Diego State University, PhD Program in Public Health (Epidemiology), 9500 Gilman Drive, La Jolla, CA 92093, CA, USA.
University of California, San Diego, Department of Pediatrics, La Jolla, CA, USA.
Public Health Nutr. 2019 Feb;22(2):344-353. doi: 10.1017/S1368980018003087. Epub 2018 Nov 26.
The present longitudinal study assessed whether changes in socio-economic status (SES) from infancy to adolescence were associated with plasma lipoprotein concentrations in adolescence, of which low HDL-cholesterol (HDL-C) and high LDL-cholesterol (LDL-C), TAG and total cholesterol (TC) concentrations are associated with higher cardiovascular risk.
SES, assessed using the modified Graffar Index, was calculated at 1, 5, 10 and 16 years. Principal components factor analysis with varimax rotation extracted two orthogonal SES factors, termed 'environmental capital' and 'social capital'. Generalized linear models were used to analyse associations between environmental and social capital at 1 and 16 years and outcomes (HDL-C, LDL-C, TAG, TC) at 16 years, as well as changes in environmental and social capital from 1-5, 5-10, 10-16 and 1-16 years, and outcomes at 16 years.
Santiago, Chile.ParticipantsWe evaluated 665 participants from the Santiago Longitudinal Study enrolled at infancy in Fe-deficiency anaemia studies and examined every 5 years to age 16 years.
Social capital in infancy was associated with higher HDL-C in adolescence. Environmental capital in adolescence was associated with higher LDL-C and TC during adolescence. Changing environmental capital from 1-16 years was associated with higher LDL-C. Changing environmental capital from 1-5 and 1-16 years was associated with higher TC.
Improvements in environmental capital throughout childhood were associated with less healthy LDL-C and TC concentrations in adolescence. We found no evidence of associations between changing environmental capital and HDL-C or TAG, or changing social capital and HDL-C, LDL-C, TAG or TC.
本纵向研究评估了从婴儿期到青少年期社会经济地位（SES）的变化是否与青少年时期的血浆脂蛋白浓度有关，其中低高密度脂蛋白胆固醇（HDL-C）和高 LDL 胆固醇（LDL-C）、TAG 和总胆固醇（TC）浓度与更高的心血管风险相关。
SES 使用改良的 Graffar 指数评估，在 1、5、10 和 16 岁时计算。使用方差极大旋转的主成分因子分析提取了两个正交的 SES 因子，称为“环境资本”和“社会资本”。广义线性模型用于分析 1 岁和 16 岁时环境和社会资本与结局（HDL-C、LDL-C、TAG、TC）之间的关系，以及 1-5、5-10、10-16 和 1-16 岁时环境和社会资本的变化与 16 岁时的结局之间的关系。
智利圣地亚哥。参与者：我们评估了来自圣地亚哥纵向研究的 665 名参与者，这些参与者在婴儿期参加了缺铁性贫血研究，并在 16 岁之前每 5 年检查一次。
婴儿期的社会资本与青少年时期更高的 HDL-C 相关。青少年时期的环境资本与青少年时期更高的 LDL-C 和 TC 相关。从 1 岁到 16 岁，环境资本的变化与 LDL-C 升高有关。从 1 岁到 5 岁和 1 岁到 16 岁，环境资本的变化与 TC 升高有关。
整个儿童时期环境资本的改善与青少年时期 LDL-C 和 TC 浓度更不健康有关。我们没有发现环境资本变化与 HDL-C 或 TAG 或社会资本与 HDL-C、LDL-C、TAG 或 TC 之间存在关联的证据。
