Department of Medical Biotechnology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Department of Medical Oncology, S. Maria della Misericordia Hospital, Perugia, Italy.
Trends Endocrinol Metab. 2019 Jan;30(1):12-24. doi: 10.1016/j.tem.2018.10.004. Epub 2018 Nov 22.
Cancer is the second leading cause of death in western countries, and thus represents a major global public health issue. Whilst it is well-recognized that diet, obesity, and smoking are risk factors for cancer, the role of low levels of high-density lipoprotein cholesterol (HDL-C) in cancer is less well appreciated. Conflicting evidence suggests that serum HDL-C levels may be either positively or negatively associated with cancer incidence and mortality. Such disparate associations are supported in part by the multitude of high-density lipoprotein (HDL) functions that can all have an impact on cancer cell biology. The aim of this review is to provide a comprehensive overview of the crosstalk between HDLs and cancer, focusing on the molecular mechanisms underlying this association.
癌症是西方国家的第二大死亡原因，因此也是一个主要的全球公共卫生问题。尽管人们已经认识到饮食、肥胖和吸烟是癌症的风险因素，但人们对低水平高密度脂蛋白胆固醇（HDL-C）在癌症中的作用认识不足。相互矛盾的证据表明，血清 HDL-C 水平与癌症的发病率和死亡率可能呈正相关或负相关。这种差异的关联在一定程度上得到了高密度脂蛋白 (HDL) 众多功能的支持，这些功能都可能对癌细胞生物学产生影响。本综述的目的是全面概述 HDL 与癌症之间的相互作用，重点介绍这种关联的分子机制。
