ST131 导致的肠道定植：危险因素和流行率。
Intestinal colonization due to ST131: risk factors and prevalence.
机构信息
1Unidad Clínica de Enfermedades Infecciosas y Microbiología, Hospital Universitario Virgen Macarena, Seville, Spain.
2Departamentos de Medicina y Microbiología, Universidad de Sevilla / CSIC/ Instituto de Biomedicina de Sevilla, Seville, Spain.
出版信息
Antimicrob Resist Infect Control. 2018 Nov 15;7:135. doi: 10.1186/s13756-018-0427-9. eCollection 2018.
BACKGROUND
sequence type 131 (ST131) is a successful clonal group that has dramatically spread during the last decades and is considered an important driver for the rapid increase of quinolone resistance in .
METHODS
Risk factors for rectal colonization by ST131 (irrespective of ESBL production) were investigated in 64 household members (18 were colonized) and 54 hospital contacts (HC; 10 colonized) of 34 and 30 index patients with community and nosocomial infection due to these organisms, respectively, using multilevel analysis with a p limit of < 0.1.
RESULT
Colonization among household members was associated with the use of proton-pump inhibitors (PPI) by the household member (OR = 3.08; 95% CI: 0.88-10.8) and higher age of index patients (OR = 1.05; 95% CI; 1.01-1.10), and among HC, with being bed-ridden (OR = 21.1; 95% CI: 3.61-160.0) and having a urinary catheter (OR = 8.4; 95% CI: 0.87-76.9).
CONCLUSION
Use of PPI and variables associated with higher need of person-to-person contact are associated with increased risk of rectal colonization by ST131. These results should be considered for infection control purposes.
背景
序列类型 131（ST131）是一个成功的克隆群，在过去几十年中迅速传播，被认为是导致喹诺酮类耐药性迅速增加的重要驱动因素。
方法
使用多级分析方法，对 34 名社区感染和 30 名医院感染的指数患者（分别为这些病原体引起的社区感染和医院感染）的 64 名家庭成员（18 名定植）和 54 名医院接触者（HC；10 名定植）的 ST131（无论是否产生 ESBL）直肠定植的危险因素进行了调查，p 值限制为<0.1。
结果
家庭成员的定植与家庭成员使用质子泵抑制剂（PPI）（OR=3.08；95%CI：0.88-10.8）和指数患者年龄较高（OR=1.05；95%CI；1.01-1.10）有关，而在 HC 中，与卧床（OR=21.1；95%CI：3.61-160.0）和留置导尿管（OR=8.4；95%CI：0.87-76.9）有关。
结论
使用 PPI 和与更高人际接触需求相关的变量与 ST131 直肠定植的风险增加有关。这些结果应在感染控制方面加以考虑。
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