Visweswaran Shyam, Becich Michael J, D'Itri Vincent S, Sendro Elaina R, MacFadden Douglas, Anderson Nicholas R, Allen Karen A, Ranganathan Dipti, Murphy Shawn N, Morrato Elaine H, Pincus Harold A, Toto Robert, Firestein Gary S, Nadler Lee M, Reis Steven E
Department of Biomedical Informatics, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
The Chartis Group, Chicago, Illinois, USA.
JAMIA Open. 2018 Oct;1(2):147-152. doi: 10.1093/jamiaopen/ooy033. Epub 2018 Aug 21.
The Accrual to Clinical Trials (ACT) network is a federated network of sites from the National Clinical and Translational Science Award (CTSA) Consortium that has been created to significantly increase participant accrual to multi-site clinical trials. The ACT network represents an unprecedented collaboration among diverse CTSA sites. The network has created governance and regulatory frameworks and a common data model to harmonize electronic health record (EHR) data, and deployed a set of Informatics for Integrating Biology and the Bedside (i2b2) data repositories that are linked by the Shared Health Research Information Network (SHRINE) platform. It provides investigators the ability to query the network in real time and to obtain aggregate counts of patients who meet clinical trial inclusion and exclusion criteria from sites across the United States. The ACT network infrastructure provides a basis for cohort discovery and for developing new informatics tools to identify and recruit participants for multi-site clinical trials.
临床试验入组（ACT）网络是一个由国家临床与转化科学奖（CTSA）联盟各站点组成的联合网络，其设立目的是大幅增加多中心临床试验的受试者入组人数。ACT网络代表了不同CTSA站点之间前所未有的合作。该网络创建了治理和监管框架以及通用数据模型，以协调电子健康记录（EHR）数据，并部署了一组通过共享健康研究信息网络（SHRINE）平台链接的整合生物学与床边信息学（i2b2）数据存储库。它为研究人员提供了实时查询该网络的能力，以及获取来自美国各地符合临床试验纳入和排除标准患者总数的能力。ACT网络基础设施为队列发现以及开发新的信息学工具以识别和招募多中心临床试验参与者提供了基础。
