Browder W, Williams D
J Natl Med Assoc. 1988 May;80(5):531-6.
A review of both the healthy and altered immune response as it relates to the surgical patient is presented. An increasing number of immunosuppressive states have been defined in the surgical patient including trauma, burns, sepsis, malnutrition, cancer, and, more recently, acquired immunodeficiency syndrome (AIDS).Investigations of the healthy and altered immune response have led to the development of immunopharmacology, which involves the study of pharmacologic agents that modify host immune response to achieve desired therapeutic goals. Endogenous and exogenous immunomodulators are described that affect uniquely the host immune response as well as their therapeutic implications.
本文综述了与外科患者相关的正常和改变的免疫反应。外科患者中已确定的免疫抑制状态越来越多，包括创伤、烧伤、败血症、营养不良、癌症，以及最近出现的获得性免疫缺陷综合征（艾滋病）。对正常和改变的免疫反应的研究导致了免疫药理学的发展，免疫药理学涉及对改变宿主免疫反应以实现预期治疗目标的药物制剂的研究。文中描述了内源性和外源性免疫调节剂，它们对宿主免疫反应有独特影响及其治疗意义。
