Hansbrough J, Peterson V, Zapata-Sirvent R, Claman H N
Surgery. 1984 Mar;95(3):290-6.
We used a model of full-thickness burn injury in the mouse and quantitated cell-mediated immunity (CMI) by measuring the degree of sensitization to the contact antigen, 2,4-dinitrofluorobenzene (DNFB). Our previous studies have shown that CMI in the burned mouse is severely suppressed. Using this immunosuppression model, we were able to significantly restore CMI by treating animals following the burn injury either with one of the nonsteroidal anti-inflammatory drugs ibuprofen or indomethacin or with the cytotoxic alkylating agent cyclophosphamide. These drugs probably restore CMI by inhibiting generation of suppressor T lymphocytes in the burned host.
我们采用小鼠全层烧伤模型，并通过测量对接触性抗原2,4-二硝基氟苯（DNFB）的致敏程度来定量细胞介导免疫（CMI）。我们之前的研究表明，烧伤小鼠的CMI受到严重抑制。利用这种免疫抑制模型，我们通过在烧伤后用非甾体抗炎药布洛芬或吲哚美辛之一，或用细胞毒性烷化剂环磷酰胺治疗动物，能够显著恢复CMI。这些药物可能通过抑制烧伤宿主中抑制性T淋巴细胞的生成来恢复CMI。
