Faraji Mehrab, Karimi Dehkordi Saeid, Zamiani Moghadam Abdol Karim, Ahmadipour Behnam, Khajali Fariborz
Department of Animal Science, Faculty of Agriculture, Shahrekord University, Shahrekord, Iran.
Department of Clinical Science, Faculty of Veterinary Medicine, Shahrekord University, Shahrekord, Iran.
J Anim Physiol Anim Nutr (Berl). 2019 Jan;103(1):162-169. doi: 10.1111/jpn.13020. Epub 2018 Nov 25.
High levels of guanidinoacetate acid (GAA) deteriorate growth response in broiler chickens. We propose using coenzyme Q , an antioxidant, and taurine (TAU), a methyl donor, to cope with the situation when high level of GAA included in diet. GAA was supplemented at 0 (control), 0.75, 1.5 and 2.25 g/kg in isoenergetic and isonitrogenous diets and fed to broilers (Cobb 500) from 1 to 40 days post-hatch. Three additional diets were prepared by adding CoQ (40 mg/kg), TAU (40 mg/kg) or their combination (both CoQ and TAU at 40 mg/kg) to the 2.25 g/kg GAA group. The experimental design used was a completely randomized design. While weight gain (p = 0.038) and feed conversion ratio (p = 0.024) improved when GAA added at 1.5 g/kg, higher supplementation (2.25 g/kg) deteriorated these responses. These responses, however, were significantly restored by using CoQ , TAU or their combination. Abdominal fat deposition was significantly decreased when TAU added to broiler diets by virtue of upregulating peroxisome proliferator-activated receptor alpha. Supplementing broiler diets with CoQ and TAU or their combination significantly decrease ascites mortality. In conclusion, CoQ and TAU have shown beneficial effects when high level of GAA included in broiler diets.
高浓度的胍基乙酸（GAA）会使肉鸡的生长反应变差。我们建议使用抗氧化剂辅酶Q和甲基供体牛磺酸（TAU）来应对日粮中含有高水平GAA的情况。在等能量和等氮日粮中分别添加0（对照）､0.75､1.5和2.25 g/kg的GAA，并在孵化后1至40天饲喂肉鸡（科宝500）。另外，在2.25 g/kg GAA组的日粮中添加辅酶Q（40 mg/kg）､牛磺酸（40 mg/kg）或它们的组合（辅酶Q和牛磺酸均为40 mg/kg），制备了三种额外的日粮。采用的实验设计为完全随机设计。当添加1.5 g/kg的GAA时，体重增加（p = 0.038）和饲料转化率（p = 0.024）有所改善，但更高的添加量（2.25 g/kg）则使这些反应变差。然而，使用辅酶Q､牛磺酸或它们的组合可显著恢复这些反应。通过上调过氧化物酶体增殖物激活受体α，在肉鸡日粮中添加牛磺酸可显著降低腹部脂肪沉积。在肉鸡日粮中添加辅酶Q和牛磺酸或它们的组合可显著降低腹水死亡率。总之，当肉鸡日粮中含有高水平GAA时，辅酶Q和牛磺酸已显示出有益作用。
