Framingham Heart Study, Framingham, Massachusetts, USA.
Population Studies Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, National Institutes of Health, Framingham, Massachusetts, USA.
Obesity (Silver Spring). 2019 Jan;27(1):137-144. doi: 10.1002/oby.22326. Epub 2018 Nov 25.
This study aimed to determine the relation of maternal prepregnancy weight with offspring BMI across adulthood from almost 40 years of follow-up.
BMI was measured in Framingham Heart Study Offspring cohort participants between 1971 and 2008. The association of maternal prepregnancy weight category (ascertained via direct measure and questionnaire) with serial offspring BMI, overweight, obesity, and change in BMI over time was tested, adjusted for age, sex, and a BMI genetic risk score; secondary models additionally adjusted for physical activity, dietary factors, smoking, education, and familial relatedness.
Among 863 participants at initial assessment (83 exposed and 780 controls), mean (SD) age was 33 (10) years, 53% were female, and mean BMI was 24.5 (4.1) kg/m . Exposed offspring BMI was higher at every examination cycle, ranging from 1.5 (0.5) to 3.0 (0.5) kg/m (P < 0.001), with larger differences at later assessments. The rate of increase in offspring BMI over time was higher in exposed offspring before the age of 50 years (β [SE] = 0.07 [0.02] kg/m per year; P = 0.004) but not after the age of 50 years (-0.05 [0.04] kg/m per year; P = 0.2).
Maternal prepregnancy weight is associated with greater offspring BMI throughout adulthood, with more rapid weight acceleration in early and midadulthood.
本研究旨在通过近 40 年的随访，确定母亲孕前体重与后代成年后 BMI 的关系。
在弗雷明汉心脏研究后代队列参与者中于 1971 年至 2008 年间测量 BMI。通过直接测量和问卷调查确定的母亲孕前体重类别（确定的）与连续后代 BMI、超重、肥胖以及随时间变化的 BMI 变化之间的关联进行了测试，调整了年龄、性别和 BMI 遗传风险评分；次要模型还调整了身体活动、饮食因素、吸烟、教育和家族相关性。
在最初评估的 863 名参与者（83 名暴露组和 780 名对照组）中，平均（SD）年龄为 33（10）岁，53%为女性，平均 BMI 为 24.5（4.1）kg/m。暴露组后代的 BMI 在每个检查周期都更高，范围从 1.5（0.5）到 3.0（0.5）kg/m（P < 0.001），后期评估的差异更大。暴露组后代的 BMI 随时间的增长速度在 50 岁之前更高（β [SE] = 0.07 [0.02]kg/m 每年；P = 0.004），但在 50 岁之后则没有（-0.05 [0.04]kg/m 每年；P = 0.2）。
母亲孕前体重与后代成年后的 BMI 相关，在成年早期和中期体重加速更快。
