Connective Tissue Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Biotechnology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Mod Rheumatol. 2019 Nov;29(6):943-948. doi: 10.1080/14397595.2018.1551107. Epub 2019 Jan 3.
Considering the important role of serum soluble receptor for advanced glycation end product (sRAGE/RAGE)-ligand system in rheumatoid arthritis (RA), this study aimed to evaluate serum sRAGE levels in RA patients compared to healthy subjects and to assess whether there is an association between sRAGE levels and disease characteristics in RA. In this cross-sectional study, 60 RA patients according to the ACR/EULAR 2010 criteria and 30 age- and sex-matched healthy controls were included. In patients, clinical examination was performed and disease activity score 28 (DAS-28) measure of disease activity was assessed. Serum sRAGE level was measured using ELISA kit. The mean ± SD age of patients and controls was 54.86 ± 11.65 and 50.71 ± 3.72 years, respectively). Serum sRAGE level was significantly higher in RA patients (median [25th and 75th percentiles], 1000.3 [792.00, 1486.8]) compared to healthy controls (median [25th and 75th percentiles], 293.25 [220.35, 364.24]) ( < .001). There was significant difference in serum sRAGE level according to the activity of disease ( < .001). There were significant positive correlations between serum sRAGE level with disease activity ( = 0.67, < .001), ESR ( = 0.411, = .001) and CRP ( = 0.273, = .035). There were no significant correlations between serum sRAGE level with demographic characteristics as well as biochemical measurements including serum creatinine, BUN, RF, and Anti-CCP ( > .05). Our study revealed higher serum sRAGE levels in RA patients compared to healthy controls, which correlated positively with disease activity.
考虑到血清可溶性晚期糖基化终产物受体（sRAGE/RAGE-配体）系统在类风湿关节炎（RA）中的重要作用，本研究旨在评估 RA 患者与健康对照者之间的血清 sRAGE 水平，并评估 sRAGE 水平与 RA 患者疾病特征之间的相关性。在这项横断面研究中，纳入了 60 名符合 ACR/EULAR 2010 标准的 RA 患者和 30 名年龄和性别匹配的健康对照者。对患者进行临床检查，并评估疾病活动评分 28（DAS-28）来衡量疾病活动度。采用 ELISA 试剂盒检测血清 sRAGE 水平。患者和对照组的平均（ ± 标准差）年龄分别为 54.86 ± 11.65 和 50.71 ± 3.72 岁。与健康对照组（中位数[25 百分位数和 75 百分位数]，293.25 [220.35，364.24]）相比，RA 患者的血清 sRAGE 水平明显更高（中位数[25 百分位数和 75 百分位数]，1000.3 [792.00，1486.8]）（ < .001）。血清 sRAGE 水平根据疾病的活动度存在显著差异（ < .001）。血清 sRAGE 水平与疾病活动度呈显著正相关（ = 0.67， < .001），与 ESR（ = 0.411， = .001）和 CRP（ = 0.273， = .035）呈显著正相关。血清 sRAGE 水平与人口统计学特征以及包括血清肌酐、BUN、RF 和抗 CCP 在内的生化指标之间无显著相关性（ > .05）。我们的研究表明，RA 患者的血清 sRAGE 水平高于健康对照组，且与疾病活动度呈正相关。
