Hebei Key Laboratory for Organ Fibrosis Research, School of Public Health, North China University of Science and Technology, Tangshan 063210, China.
Department of Internal Medicine Nursing, School of Nursing, Wannan Medical College, 22 Wenchang West Road, Higher Education Park, Wuhu 241002, China.
Molecules. 2022 Aug 2;27(15):4922. doi: 10.3390/molecules27154922.
As a critical molecule in the onset and sustainment of inflammatory response, the receptor for advanced glycation end products (RAGE) has a variety of ligands, such as advanced glycation end products (AGEs), S100/calcium granule protein, and high-mobility group protein 1 (HMGB1). Recently, an increasing number studies have shown that RAGE ligand binding can initiate the intracellular signal cascade, affect intracellular signal transduction, stimulate the release of cytokines, and play a vital role in the occurrence and development of immune-related diseases, such as systemic lupus erythematosus, rheumatoid arthritis, and Alzheimer's disease. In addition, other RAGE signaling pathways can play crucial roles in life activities, such as inflammation, apoptosis, autophagy, and endoplasmic reticulum stress. Therefore, the strategy of targeted intervention in the RAGE signaling pathway may have significant therapeutic potential, attracting increasing attention. In this paper, through the systematic induction and analysis of RAGE-related signaling pathways and their regulatory mechanisms in immune-related diseases, we provide theoretical clues for the follow-up targeted intervention of RAGE-mediated diseases.
作为炎症反应发生和持续的关键分子，晚期糖基化终产物（RAGE）受体有多种配体，如晚期糖基化终产物（AGEs）、S100/钙颗粒蛋白和高迁移率族蛋白 1（HMGB1）。最近，越来越多的研究表明，RAGE 配体结合可以启动细胞内信号级联反应，影响细胞内信号转导，刺激细胞因子的释放，并在免疫相关疾病（如系统性红斑狼疮、类风湿关节炎和阿尔茨海默病）的发生和发展中发挥重要作用。此外，其他 RAGE 信号通路在生命活动中也起着至关重要的作用，如炎症、细胞凋亡、自噬和内质网应激。因此，靶向干预 RAGE 信号通路的策略可能具有显著的治疗潜力，引起了越来越多的关注。本文通过对 RAGE 相关信号通路及其在免疫相关性疾病中的调节机制进行系统的诱导和分析，为后续 RAGE 介导疾病的靶向干预提供了理论线索。
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