Bose Bipasha, Najwa Abdur Rashid, Shenoy P Sudheer
Stem Cells and Regenerative Medicine Centre, Yenepoya Research Centre, Yenepoya (Deemed to be University), University Road, Derlakatte, Mangalore, Karnataka, 575018, India.
College of Medicine, Princess Nourah bint Abdulrahman University, Riyadh, 11671, Kingdom of Saudi Arabia.
Mol Biotechnol. 2019 Feb;61(2):145-152. doi: 10.1007/s12033-018-0136-x.
The surface of the eye is continuously exposed to the harshness of the external environment. As a homeostatic mechanism for replenishing the worn off cells of the ocular surface, a balance is maintained via the role of ocular stem cells. However, under extreme conditions of harshness like exposure to bright and ultraviolet light, the ocular stem cells are unable to do the repair mechanisms resulting in severe impairment of vision and disturbances in the eye. This work reappraises the recent understandings of mechanisms of oxidative damages caused to the ocular stem cells by UV/bright light and their probable mitigation.
眼睛表面持续暴露于外部环境的恶劣条件下。作为补充眼表磨损细胞的一种稳态机制，通过眼干细胞的作用维持着一种平衡。然而，在诸如暴露于强光和紫外线下等极端恶劣条件下，眼干细胞无法进行修复机制，从而导致严重的视力损害和眼部紊乱。这项工作重新评估了近期对紫外线/强光对眼干细胞造成氧化损伤的机制及其可能的缓解措施的认识。
