胚胎干细胞和诱导多能干细胞衍生的 3D 视网膜片移植到视网膜退行性病变的小鼠中。
Transplantation of embryonic and induced pluripotent stem cell-derived 3D retinal sheets into retinal degenerative mice.
机构信息
Laboratory for Retinal Regeneration, RIKEN Center for Developmental Biology, Kobe 650-0047, Japan ; Graduate School of Medicine, Kyoto University, Kyoto 606-8501, Japan.
Laboratory for Retinal Regeneration, RIKEN Center for Developmental Biology, Kobe 650-0047, Japan.
出版信息
Stem Cell Reports. 2014 Apr 24;2(5):662-74. doi: 10.1016/j.stemcr.2014.03.011. eCollection 2014 May 6.
In this article, we show that mouse embryonic stem cell- or induced pluripotent stem cell-derived 3D retinal tissue developed a structured outer nuclear layer (ONL) with complete inner and outer segments even in an advanced retinal degeneration model (rd1) that lacked ONL. We also observed host-graft synaptic connections by immunohistochemistry. This study provides a "proof of concept" for retinal sheet transplantation therapy for advanced retinal degenerative diseases.
在本文中，我们展示了源自小鼠胚胎干细胞或诱导多能干细胞的 3D 视网膜组织在缺乏外核层（ONL）的晚期视网膜变性模型（rd1）中也能形成具有完整内、外节的结构化外核层（ONL）。我们还通过免疫组织化学观察到了宿主-移植物的突触连接。这项研究为晚期视网膜退行性疾病的视网膜片移植治疗提供了“概念验证”。
Zotero 插件