Sino-German Joint Research Lab for Space Biomaterials, and Translational Technology, School of Life Sciences, Northwestern Polytechnical University, 127 Youyi Xilu, Xi'an, Shaanxi, 710072, P. R. China.
Institute of Microbiology, Technische Universität Dresden, Zellescher Weg 20b, 01217, Dresden, Germany.
Chemistry. 2019 Feb 1;25(7):1716-1721. doi: 10.1002/chem.201805680. Epub 2019 Jan 2.
In cooperative catalysis, the combination of chemo- and biocatalysts to perform one-pot reactions is a powerful tool for the improvement of chemical synthesis. Herein, UiO-66-NH was employed to stepwise immobilize Pd nanoparticles (NPs) and Candida antarctica lipase B (CalB) for the fabrication of biohybrid catalysts for cascade reactions. Distinct from traditional materials, UiO-66-NH has a robust but tunable structure that can be utilized with a ligand exchange approach to adjust its hydrophobicity, resulting in excellent catalyst dispersity in diverse reaction media. These attractive properties contribute to the formation of MOF-based biohybrid catalysts with high activity and selectivity in the synthesis of benzyl hexanoate from benzaldehyde and ethyl hexanoate. With this proof-of-concept, we reasonably expect that future tailor-made MOFs can combine other catalysts, ranging from chemical to biological catalysts for applications in industry.
在协同催化中，将化学催化剂和生物催化剂组合在一起进行一锅反应是改进化学合成的有力工具。在此，采用 UiO-66-NH 逐步固定化钯纳米粒子 (NPs) 和南极假丝酵母脂肪酶 B (CalB)，用于制备用于级联反应的生物杂化催化剂。与传统材料不同，UiO-66-NH 具有坚固但可调节的结构，可以采用配体交换方法来调整其疏水性，从而在各种反应介质中实现出色的催化剂分散性。这些吸引人的特性有助于形成基于 MOF 的生物杂化催化剂，在苯甲醛和己酸乙酯合成苯甲酸己酯的反应中具有高活性和选择性。有了这个概念验证，我们有理由期望未来定制的 MOF 可以结合其他催化剂，从化学催化剂到生物催化剂，应用于工业领域。
