Matsumura Shinichi, Murata Kazuya, Zaima Nobuhiro, Yoshioka Yuri, Morimoto Masanori, Matsuda Hideaki, Iwaki Masahiro
Nat Prod Commun. 2016 Nov;11(11):1671-1674.
The need for a preventive agent against dementia led us to screen natural plant resources. Among the herbs and spices tested, sesame seed prepared from Sesamum indicum seeds showed potent β-secretase inhibitory activity. The active principles were determined to be sesamin and sesamolin, typical lignans in S. indicum. The IC(50) values of sesamin and sesamolin were 257 and 140 μM, respectively. These compounds were investigated in a preliminary absorption experiment. After oral administration, these compounds were detected in an intact form in the brain and serum. These results suggest that consumption of sesame seeds may prevent dementia by sesamin and sesamolin, the constituents in sesame seeds.
对预防痴呆症药物的需求促使我们筛选天然植物资源。在所测试的药草和香料中，由芝麻籽制备的芝麻显示出强大的β-分泌酶抑制活性。活性成分被确定为芝麻素和芝麻林素，它们是芝麻中的典型木脂素。芝麻素和芝麻林素的半数抑制浓度（IC50）值分别为257和140μM。在初步吸收实验中对这些化合物进行了研究。口服给药后，这些化合物在大脑和血清中以完整形式被检测到。这些结果表明，食用芝麻籽可能通过芝麻籽中的成分芝麻素和芝麻林素预防痴呆症。
