Matsumura Shinichi, Murata Kazuya, Zaima Nobuhiro, Yoshioka Yuri, Morimoto Masanori, Kugo Hirona, Yamamoto Ayami, Moriyama Tatsuya, Matsuda Hideaki
Nat Prod Commun. 2016 Dec;11(12):1785-1788.
The need for a preventive agent against dementia led us to screen natural plant resources. Among the herbs and spices tested, turmeric, from rhizomes of Curcuma longa, showed high potency against β-secretase. The active principles were determined as α-turmerone, β-turmerone and ar-turmerone, with IC(50) values of 39, 62 and 92 μM respectively. In this study, the efficiency of collecting the essential oil using steam distillation of the volatile substance was disclosed The active principles were explored, and four sesquiterpenoids and five monoterpenoids were revealed as active principles against β-secretase; On the other hand, α-turmerone, β-turmerone and ar-turmerone were also investigated in a pharmacokinetic absorption experiment. After oral administration, these compounds were detected in an intact form in the brain and serum. These results suggest that consumption of-turieric constituents may prevent dementia.
对预防痴呆症药物的需求促使我们筛选天然植物资源。在所测试的药草和香料中，来自姜黄根茎的姜黄对β-分泌酶显示出高效能。活性成分被确定为α-姜黄酮、β-姜黄酮和ar-姜黄酮，其IC(50)值分别为39、62和92μM。在本研究中，揭示了通过挥发性物质的水蒸气蒸馏收集精油的效率。对活性成分进行了探索，发现四种倍半萜类化合物和五种单萜类化合物是针对β-分泌酶的活性成分；另一方面，还对α-姜黄酮、β-姜黄酮和ar-姜黄酮进行了药代动力学吸收实验。口服给药后，这些化合物在大脑和血清中以完整形式被检测到。这些结果表明，食用姜黄成分可能预防痴呆症。
