补充蛋白质能否使营养不良的（虚弱前期）老年人体重和功能得到具有临床意义的改善？ - Suppr

Can protein supplementation lead to clinically meaningful improvements in muscle mass and function in undernourished (pre)frail elderly?

作者信息

Daly Robin M, Nowson Caryl A

机构信息

Institute for Physical Activity and Nutrition, School of Exercise and Nutrition Sciences, Deakin University, Geelong, Victoria, Australia.

出版信息

Am J Clin Nutr. 2018 Nov 1;108(5):911-912. doi: 10.1093/ajcn/nqy289.

DOI:10.1093/ajcn/nqy289

PMID:30475971

Abstract

摘要

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Can protein supplementation lead to clinically meaningful improvements in muscle mass and function in undernourished (pre)frail elderly?补充蛋白质能否使营养不良的（虚弱前期）老年人体重和功能得到具有临床意义的改善？

Am J Clin Nutr. 2018 Nov 1;108(5):911-912. doi: 10.1093/ajcn/nqy289.

Protein supplementation improves muscle mass and physical performance in undernourished prefrail and frail elderly subjects: a randomized, double-blind, placebo-controlled trial.补充蛋白质可改善营养不良的衰弱前期和衰弱老年人的肌肉量和身体机能：一项随机、双盲、安慰剂对照试验。

Am J Clin Nutr. 2018 Nov 1;108(5):1026-1033. doi: 10.1093/ajcn/nqy214.

Protein supplementation increases muscle mass gain during prolonged resistance-type exercise training in frail elderly people: a randomized, double-blind, placebo-controlled trial.补充蛋白质可增加虚弱老年人在长期抗阻型运动训练期间的肌肉量增加：一项随机、双盲、安慰剂对照试验。

J Am Med Dir Assoc. 2012 Oct;13(8):713-9. doi: 10.1016/j.jamda.2012.05.020. Epub 2012 Jul 6.

Protein supplementation improves physical performance in frail elderly people: a randomized, double-blind, placebo-controlled trial.补充蛋白质可改善虚弱老年人的身体机能：一项随机、双盲、安慰剂对照试验。

J Am Med Dir Assoc. 2012 Oct;13(8):720-6. doi: 10.1016/j.jamda.2012.07.005. Epub 2012 Aug 11.

Combined effects of functionally-oriented exercise regimens and nutritional supplementation on both the institutionalised and free-living frail elderly (double-blind, randomised clinical trial).功能导向性运动方案与营养补充对机构养老及居家体弱老年人的联合作用（双盲随机临床试验）

BMC Public Health. 2009 Jan 28;9:39. doi: 10.1186/1471-2458-9-39.

Effects and feasibility of exercise therapy combined with branched-chain amino acid supplementation on muscle strengthening in frail and pre-frail elderly people requiring long-term care: a crossover trial.运动疗法联合补充支链氨基酸对需要长期护理的体弱和准体弱老年人肌肉强化的效果及可行性：一项交叉试验

Appl Physiol Nutr Metab. 2016 Apr;41(4):438-45. doi: 10.1139/apnm-2015-0436. Epub 2016 Jan 5.

Effects of testosterone on muscle strength, physical function, body composition, and quality of life in intermediate-frail and frail elderly men: a randomized, double-blind, placebo-controlled study.睾酮对中年和体弱老年男性肌肉力量、身体功能、身体成分和生活质量的影响：一项随机、双盲、安慰剂对照研究。

J Clin Endocrinol Metab. 2010 Feb;95(2):639-50. doi: 10.1210/jc.2009-1251. Epub 2010 Jan 8.

Supplement-based nutritional strategies to tackle frailty: A multifactorial, double-blind, randomized placebo-controlled trial.基于补充剂的营养策略应对衰弱：一项多因素、双盲、随机安慰剂对照试验。

Clin Nutr. 2021 Aug;40(8):4849-4858. doi: 10.1016/j.clnu.2021.06.024. Epub 2021 Jul 3.

Low vitamin D status is associated with reduced muscle mass and impaired physical performance in frail elderly people.维生素 D 水平低与虚弱老年人的肌肉减少和身体机能受损有关。

Eur J Clin Nutr. 2013 Oct;67(10):1050-5. doi: 10.1038/ejcn.2013.144. Epub 2013 Aug 14.

Effects of exercise and/or β-hydroxy-β-methylbutyrate supplementation on muscle mass, muscle strength, and physical performance in older women with low muscle mass: a randomized, double-blind, placebo-controlled trial.运动和/或 β-羟基-β-甲基丁酸补充对低肌肉量老年女性肌肉量、肌肉力量和身体机能的影响：一项随机、双盲、安慰剂对照试验。

Am J Clin Nutr. 2021 Oct 4;114(4):1371-1385. doi: 10.1093/ajcn/nqab176.

引用本文的文献

Relationship between frailty, nutrition, body composition, quality of life, and gender in institutionalized older people.机构养老老年人的衰弱、营养、身体成分、生活质量与性别的关系。

Aging Clin Exp Res. 2022 Jun;34(6):1357-1363. doi: 10.1007/s40520-022-02077-0. Epub 2022 Feb 11.

Animal Protein versus Plant Protein in Supporting Lean Mass and Muscle Strength: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.动物蛋白与植物蛋白在支持瘦体重和肌肉力量方面的比较：一项随机对照试验的系统评价和荟萃分析。

Nutrients. 2021 Feb 18;13(2):661. doi: 10.3390/nu13020661.

The sarcopenia and physical frailty in older people: multi-component treatment strategies (SPRINTT) project: description and feasibility of a nutrition intervention in community-dwelling older Europeans.老年人肌少症和身体虚弱：多组分治疗策略（SPRINTT）项目：一项针对社区居住的老年欧洲人的营养干预措施的描述和可行性。

Eur Geriatr Med. 2021 Apr;12(2):303-312. doi: 10.1007/s41999-020-00438-4. Epub 2021 Feb 13.

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Can protein supplementation lead to clinically meaningful improvements in muscle mass and function in undernourished (pre)frail elderly?

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