1] Top Institute Food and Nutrition, Wageningen, The Netherlands [2] Division of Human Nutrition, Wageningen University, Wageningen, The Netherlands.
Eur J Clin Nutr. 2013 Oct;67(10):1050-5. doi: 10.1038/ejcn.2013.144. Epub 2013 Aug 14.
BACKGROUND/OBJECTIVES: Serum 25-hydroxyvitamin D (25(OH)D) status has been associated with muscle mass, strength and physical performance in healthy elderly people. Yet, in pre-frail and frail elderly people this association has not been studied. The objective of this study was to explore the association between vitamin D intake and serum 25(OH)D status with muscle mass, strength and physical performance in a pre-frail and frail elderly population.
SUBJECTS/METHODS: This cross-sectional study included 127 pre-frail and frail elderly people in The Netherlands. Whole body and appendicular lean mass (ALM) (dual energy X-ray absorptiometry), leg strength (one repetition maximum), handgrip strength and physical performance (short physical performance battery) were measured, and blood samples were collected for the assessment of serum 25(OH)D status (liquid chromatography-tandem mass spectrometry). In addition, habitual dietary intake (3-day food records) and physical activity data (accelerometers) were collected.
In total, 53% of the participants had a serum 25(OH)D level below 50 nmol/l. After adjustment for confounding factors, 25(OH)D status was associated with ALM (β=0.012, P=0.05) and with physical performance (β=0.020, P<0.05). Vitamin D intake was associated with physical performance (β=0.18, P<0.05) but not with ALM (P>0.05).
In this frail elderly population, 25(OH)D status is low and suggests a modest association with reduced ALM and impaired physical performance. In addition, vitamin D intake tended to be associated with impaired physical performance. Our findings highlight the need for well-designed intervention trials to assess the impact of vitamin D supplementation on 25(OH)D status, muscle mass and physical performance in pre-frail and frail elderly people.
背景/目的：血清 25-羟维生素 D（25(OH)D）水平与健康老年人的肌肉质量、力量和身体表现有关。然而，在衰弱前期和衰弱的老年人中，这种关联尚未得到研究。本研究的目的是探讨衰弱前期和衰弱的老年人中维生素 D 摄入量和血清 25(OH)D 状态与肌肉质量、力量和身体表现的关系。
受试者/方法：本横断面研究纳入了荷兰的 127 名衰弱前期和衰弱的老年人。使用双能 X 射线吸收法（DEXA）测量全身和四肢瘦体重（ALM）、腿部力量（最大重复次数）、握力和身体表现（简短身体表现电池），并采集血液样本评估血清 25(OH)D 状态（液相色谱-串联质谱法）。此外，还收集了习惯性饮食摄入（3 天食物记录）和体力活动数据（加速度计）。
共有 53%的参与者血清 25(OH)D 水平低于 50 nmol/L。在调整混杂因素后，25(OH)D 状态与 ALM（β=0.012，P=0.05）和身体表现（β=0.020，P<0.05）相关。维生素 D 摄入量与身体表现相关（β=0.18，P<0.05），但与 ALM 无关（P>0.05）。
在这个衰弱的老年人群中，25(OH)D 状态较低，提示与 ALM 减少和身体表现受损有一定关联。此外，维生素 D 摄入量与身体表现受损有关。我们的研究结果强调需要进行精心设计的干预试验，以评估维生素 D 补充对衰弱前期和衰弱的老年人 25(OH)D 状态、肌肉质量和身体表现的影响。
