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kisspeptin-10 对参与食欲控制的下丘脑神经肽和神经递质的影响。

Effects of Kisspeptin-10 on Hypothalamic Neuropeptides and Neurotransmitters Involved in Appetite Control.

机构信息

Department of Pharmacy, "G. d'Annunzio" University, Via dei Vestini 31, 66100 Chieti, Italy.

出版信息

Molecules. 2018 Nov 24;23(12):3071. doi: 10.3390/molecules23123071.

DOI:10.3390/molecules23123071
PMID:30477219
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6321454/
Abstract

Besides its role as key regulator in gonadotropin releasing hormone secretion, reproductive function, and puberty onset, kisspeptin has been proposed to act as a bridge between energy homeostasis and reproduction. In the present study, to characterize the role of hypothalamic kisspeptin as metabolic regulator, we evaluated the effects of kisspeptin-10 on neuropeptide Y (NPY) and brain-derived neurotrophic factor (BDNF) gene expression and the extracellular dopamine (DA), norepinephrine (NE), serotonin (5-hydroxytriptamine, 5-HT), dihydroxyphenylacetic acid (DOPAC), and 5-hydroxyindoleacetic acid (5-HIIA) concentrations in rat hypothalamic (Hypo-E22) cells. Our study showed that kisspeptin-10 in the concentration range 1 nM⁻10 μM was well tolerated by the Hypo-E22 cell line. Moreover, kisspeptin-10 (100 nM⁻10 μM) concentration independently increased the gene expression of NPY while BDNF was inhibited only at the concentration of 10 μM. Finally, kisspeptin-10 decreased 5-HT and DA, leaving unaffected NE levels. The inhibitory effect on DA and 5-HT is consistent with the increased peptide-induced DOPAC/DA and 5-HIIA/5-HT ratios. In conclusion, our current findings suggesting the increased NPY together with decreased BDNF and 5-HT activity following kisspeptin-10 would be consistent with a possible orexigenic effect induced by the peptide.

摘要

除了作为促性腺激素释放激素分泌、生殖功能和青春期启动的关键调节剂的作用外，kisspeptin 还被认为是能量平衡和生殖之间的桥梁。在本研究中，为了表征下丘脑 kisspeptin 作为代谢调节剂的作用，我们评估了 kisspeptin-10 对神经肽 Y (NPY) 和脑源性神经营养因子 (BDNF) 基因表达以及细胞外多巴胺 (DA)、去甲肾上腺素 (NE)、5-羟色胺 (5-HT)、二羟苯乙酸 (DOPAC) 和 5-羟吲哚乙酸 (5-HIIA) 浓度的影响在大鼠下丘脑 (Hypo-E22) 细胞中。我们的研究表明，在 1 nM⁻10 μM 的浓度范围内，kisspeptin-10 可被 Hypo-E22 细胞系耐受。此外，kisspeptin-10 (100 nM⁻10 μM) 浓度独立增加 NPY 的基因表达，而 BDNF 仅在 10 μM 的浓度下被抑制。最后，kisspeptin-10 降低了 5-HT 和 DA，而 NE 水平不受影响。这种对 DA 和 5-HT 的抑制作用与增加的肽诱导的 DOPAC/DA 和 5-HIIA/5-HT 比值一致。总之，我们目前的研究结果表明， kisspeptin-10 后 NPY 增加，BDNF 和 5-HT 活性降低，与肽可能引起的食欲增加效应一致。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0502/6321454/137da865e3e1/molecules-23-03071-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0502/6321454/a6ac8c2317b2/molecules-23-03071-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0502/6321454/98c8437dc834/molecules-23-03071-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0502/6321454/5b7060de9f6f/molecules-23-03071-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0502/6321454/137da865e3e1/molecules-23-03071-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0502/6321454/a6ac8c2317b2/molecules-23-03071-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0502/6321454/98c8437dc834/molecules-23-03071-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0502/6321454/5b7060de9f6f/molecules-23-03071-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0502/6321454/137da865e3e1/molecules-23-03071-g004.jpg

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