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葡萄（Vitis vinifera L.）果皮水提物可调节 SW-480 细胞和分离的小鼠结肠的炎症和免疫反应。

A grape (Vitis vinifera L.) pomace water extract modulates inflammatory and immune response in SW-480 cells and isolated mouse colon.

机构信息

Department of Pharmacy, G. d'Annunzio University of Chieti-Pescara, Chieti, Italy.

Veridia Italia Srl, Pescara, Italy.

出版信息

Phytother Res. 2022 Dec;36(12):4620-4630. doi: 10.1002/ptr.7581. Epub 2022 Sep 7.

DOI:10.1002/ptr.7581
PMID:36069605
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10087928/
Abstract

Grape (Vitis vinifera L.) pomace is a residue derived from the winemaking process, which contains bioactive compounds displaying noteworthy health-promoting properties. The aim of the present study was to investigate the phenolic composition and protective effects of a water extract of grape pomace (WEGP) in colorectal cancer cell line SW480 and in isolated mouse colon exposed to Escherichia coli lipopolysaccharide (LPS). The extract decreased SW-480 cell viability, as well as vascular endothelial factor A (VEGFA), hypoxia-induced factor 1α (HIF1α), and transient receptor potential M8 (TRPM8) LPS-induced gene expression. Moreover, the extract inhibited mRNA levels of nuclear factor kB (NFkB), cyclooxygenase (COX)-2, tumor necrosis factor (TNF)α, interleukin (IL)-6, IL-1β, IL-10, inducible nitric oxide synthase (iNOS), and interferon (IFN)γ, in isolated colon. Conversely, WEGP increased the gene expression of antioxidant catalase (CAT) and superoxide dismutase (SOD), in the same model. The modulatory effects exerted by WEGP could be related, at least in part, to the phenolic composition, with particular regards to the catechin level. Docking calculations also predicted the interactions of catechin toward TRPM8 receptor, deeply involved in colon cancer; thus further suggesting the grape pomace as a valuable source of bioactive extracts and phytochemicals with protective effects in the colon.

摘要

葡萄（Vitis vinifera L.）渣是一种酿酒过程中的副产物，含有具有显著促进健康特性的生物活性化合物。本研究旨在研究葡萄渣水提物（WEGP）在结直肠癌细胞系 SW480 和暴露于大肠杆菌脂多糖（LPS）的分离小鼠结肠中的酚类成分和保护作用。该提取物降低了 SW-480 细胞活力，以及血管内皮生长因子 A（VEGFA）、缺氧诱导因子 1α（HIF1α）和瞬时受体电位 M8（TRPM8）LPS 诱导的基因表达。此外，该提取物抑制了核因子 kB（NFkB）、环氧化酶（COX）-2、肿瘤坏死因子（TNF）α、白细胞介素（IL）-6、IL-1β、IL-10、诱导型一氧化氮合酶（iNOS）和干扰素（IFN）γ在分离结肠中的mRNA 水平。相反，WEGP 增加了同一模型中抗氧化酶过氧化氢酶（CAT）和超氧化物歧化酶（SOD）的基因表达。WEGP 发挥的调节作用至少部分与其酚类成分有关，特别是儿茶素水平有关。对接计算还预测了儿茶素与 TRPM8 受体的相互作用，TRPM8 受体与结肠癌密切相关；这进一步表明葡萄渣是具有保护作用的生物活性提取物和植物化学物质的有价值来源。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e2f6/10087928/3e9d0dbe448c/PTR-36-4620-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e2f6/10087928/71f94a17b297/PTR-36-4620-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e2f6/10087928/9b30ef1b962b/PTR-36-4620-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e2f6/10087928/5c553052ac59/PTR-36-4620-g002.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e2f6/10087928/369d96b3e096/PTR-36-4620-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e2f6/10087928/3e9d0dbe448c/PTR-36-4620-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e2f6/10087928/71f94a17b297/PTR-36-4620-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e2f6/10087928/9b30ef1b962b/PTR-36-4620-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e2f6/10087928/5c553052ac59/PTR-36-4620-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e2f6/10087928/8503b13f3e8b/PTR-36-4620-g004.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e2f6/10087928/3e9d0dbe448c/PTR-36-4620-g001.jpg

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