[γ-氨基丁酸信号通路在自闭症谱系障碍中的作用综述]
[A review on the role of γ-aminobutyric acid signaling pathway in autism spectrum disorder].
作者信息
Wang Bing, Li Hong-Hua, Yue Xiao-Jing, Jia Fei-Yong, DU Lin
机构信息
Department of Developmental and Behaviorial Pediatrics, First Hospital of Jilin University, Changchun 130021, China.
出版信息
Zhongguo Dang Dai Er Ke Za Zhi. 2018 Nov;20(11):974-978. doi: 10.7499/j.issn.1008-8830.2018.11.019.
The etiology and pathogenesis of autism spectrum disorder (ASD) are not yet clear. Studies have shown that there are many neurotransmitter abnormalities in children with ASD, mainly involving in glutamate, γ-aminobutyric acid (GABA), dopamine, 5-HT and oxytocin. The imbalance of excitatory glutamatergic neurotransmitters and inhibitory GABAergic neurotransmitters is closely related to the pathogenesis of ASD. Both animal model studies and clinical studies on ASD suggest that GABA signaling pathway may play an important role in the pathogenesis of ASD. This article reviews the research on the association between GABA signaling pathway and the pathogenesis of ASD to further explore the pathogenesis of ASD and provide theoretical basis for the treatment of ASD.
自闭症谱系障碍（ASD）的病因和发病机制尚不清楚。研究表明，ASD患儿存在多种神经递质异常，主要涉及谷氨酸、γ-氨基丁酸（GABA）、多巴胺、5-羟色胺（5-HT）和催产素。兴奋性谷氨酸能神经递质和抑制性GABA能神经递质的失衡与ASD的发病机制密切相关。关于ASD的动物模型研究和临床研究均表明，GABA信号通路可能在ASD的发病机制中起重要作用。本文综述了GABA信号通路与ASD发病机制之间关联的研究，以进一步探究ASD的发病机制，并为ASD的治疗提供理论依据。
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