UMR A PAM, Équipe Vin, Aliment, Microbiologie, Stress, Université Bourgogne Franche-Comté, AgroSup Dijon, 21078 Dijon cedex, France; Parasitology-Mycology Department, University Hospital of Dijon, 21000 Dijon, France.
Department of Clinical Haematology, University Hospital of Dijon, 21000 Dijon, France.
J Mycol Med. 2018 Dec;28(4):659-662. doi: 10.1016/j.mycmed.2018.10.001. Epub 2018 Oct 26.
Trichoderma species are saprophytic filamentous fungi that can be found all over the word. These fungi show increasing medical importance as opportunistic human pathogens, particularly in immunocompromised patients. Invasive infections due to Trichoderma are rare and definitive diagnosis is complex to achieve because of the lack of specific diagnosis tools. We report in this work the first proven case of invasive pulmonary infection due to T. longibrachiatum in a 69-year-old white male with hematologic malignancy. The patient was successfully treated initially with voriconazole alone followed by a combination of voriconazole and caspofungine.
木霉属真菌是一种腐生丝状真菌，在世界各地都有发现。这些真菌作为机会性人类病原体的重要性日益增加，特别是在免疫功能低下的患者中。由于缺乏特异性诊断工具，木霉属真菌引起的侵袭性感染较为罕见，确诊较为复杂。本研究报告了首例 69 岁白人男性血液恶性肿瘤患者发生长枝木霉属所致侵袭性肺感染的确诊病例。患者最初单独使用伏立康唑治疗取得了成功，随后联合使用伏立康唑和卡泊芬净。
