Department of Vascular Medicine, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands; and.
Department of Medicine, Ottawa Hospital Research Institute, University of Ottawa, Ottawa, ON, Canada.
Blood. 2019 Jan 24;133(4):291-298. doi: 10.1182/blood-2018-08-835595. Epub 2018 Nov 26.
Venous thromboembolism (VTE), which includes deep vein thrombosis and pulmonary embolism, is a common complication of cancer and is associated with significant morbidity and mortality. Several cancer-related risk factors contribute to the development of VTE including cancer type and stage, chemotherapy, surgery, and patient-related factors such as advanced age and immobilization. Patients with cancer frequently undergo diagnostic imaging scans for cancer staging and treatment response evaluation, which is increasing the underlying risk of VTE detection. The management of cancer-associated VTE is challenging. Over the years, important advances have been made and, recently, randomized controlled trials have been published helping clinicians' management of this patient population. In this review, we will discuss common cancer-associated VTE scenarios and critically review available evidence to guide treatment decisions.
静脉血栓栓塞症(VTE)包括深静脉血栓形成和肺栓塞,是癌症的常见并发症,与显著的发病率和死亡率相关。多种与癌症相关的风险因素可导致 VTE 的发生,包括癌症类型和分期、化疗、手术,以及患者相关因素,如高龄和固定不动。癌症患者经常接受癌症分期和治疗效果评估的诊断影像学扫描,这增加了 VTE 检测的潜在风险。癌症相关 VTE 的管理具有挑战性。近年来,已经取得了重要进展,最近发表了随机对照试验,帮助临床医生管理这一患者群体。在这篇综述中,我们将讨论常见的癌症相关 VTE 情况,并批判性地回顾现有证据,以指导治疗决策。