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术后喝咖啡对腹部手术后胃肠功能的影响:系统评价和随机对照试验的荟萃分析。

Effect of postoperative coffee consumption on gastrointestinal function after abdominal surgery: A systematic review and meta-analysis of randomized controlled trials.

机构信息

Department of Obstetrics and Gynaecology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.

Department of Epidemiology and Biostatistics, Faculty of Public Health, Khon Kaen University, Khon Kaen, Thailand.

出版信息

Sci Rep. 2018 Nov 26;8(1):17349. doi: 10.1038/s41598-018-35752-2.

Abstract

Coffee is believed to prevent postoperative ileus. This systematic review and meta-analysis was undertaken to determine the effectiveness of coffee consumption in stimulating gastrointestinal function after abdominal surgery. A number of databases for randomized controlled trials comparing coffee consumption following abdominal surgery versus water drinking or no intervention were searched. Cochrane's Risk of Bias tool was used to assess risk of bias in included studies. Six trials involving 601 participants were included. All studies had high risk of performance bias. Three studies had an unclear risk of selection bias. Postoperative coffee consumption reduced time to first defecation (mean difference (MD), -9.98 hours; 95% CI, -16.97 to -2.99), time to first flatus (MD, -7.14 hours; 95% CI, -10.96 to -3.33), time to first bowel sound (MD, -4.17 hours; 95% CI, -7.88 to -0.47), time to tolerance of solid food (MD, -15.55 hours; 95% CI, -22.83 to -8.27), and length of hospital stay (MD, -0.74 days; 95% CI, -1.14 to -0.33). Benefits increased with increasing complexity of the procedure. None of the included studies reported adverse events associated with coffee consumption. Postoperative coffee consumption is effective and safe for enhancing the recovery of gastrointestinal function after abdominal surgery.

摘要

咖啡被认为可以预防术后肠麻痹。本系统评价和荟萃分析旨在确定术后饮用咖啡刺激胃肠道功能的有效性。检索了比较腹部手术后饮用咖啡与饮水或不干预的随机对照试验的多个数据库。使用 Cochrane 偏倚风险工具评估纳入研究的偏倚风险。纳入了六项涉及 601 名参与者的试验。所有研究均存在高度的实施偏倚风险。三项研究存在选择偏倚风险不明确。术后饮用咖啡可减少首次排便时间(平均差(MD),-9.98 小时;95%置信区间,-16.97 至 -2.99)、首次排气时间(MD,-7.14 小时;95%置信区间,-10.96 至 -3.33)、首次肠鸣音时间(MD,-4.17 小时;95%置信区间,-7.88 至 -0.47)、首次耐受固体食物时间(MD,-15.55 小时;95%置信区间,-22.83 至 -8.27)和住院时间(MD,-0.74 天;95%置信区间,-1.14 至 -0.33)。手术的复杂性越高,获益越大。纳入的研究均未报告与咖啡摄入相关的不良事件。术后饮用咖啡可有效且安全地促进腹部手术后胃肠道功能的恢复。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ef77/6255780/33c9ac5c8a03/41598_2018_35752_Fig1_HTML.jpg

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