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毛发中皮质醇、脱氢表雄酮和睾酮的测量:初步结果和有前景的迹象。

Measurement of cortisol, dehydroepiandrosterone, and testosterone in the hair of children: Preliminary results and promising indications.

机构信息

Melbourne School of Psychological Sciences, The University of Melbourne, Melbourne, Victoria, Australia.

Melbourne Neuropsychiatry Centre, The University of Melbourne and Melbourne Health, Melbourne, Victoria, Australia.

出版信息

Dev Psychobiol. 2019 Sep;61(6):962-970. doi: 10.1002/dev.21807. Epub 2018 Nov 26.

Abstract

Hormone analysis is a valuable tool for understanding how physiology and behavior interact. Cortisol in hair has recently been examined as a measure of longer-term hormone output. The aim of this study was to investigate the relationships between other androgens in hair and anthropometric measures. In a child sample (n = 114, mean age: 8.5 years, 66 females) levels of cortisol, dehydroepiandrosterone (DHEA) and testosterone were assayed in the 0-3 cm section proximal to scalp. The 3-6 cm segment within a subsample of female participants (n = 35) was examined and compared. Results showed that testosterone strongly correlated with DHEA, and moderately correlated with cortisol (0-3 cm only). Higher hormone concentrations were present in the 3-6 cm segment. Finally, there was a weak positive association between DHEA and height. The replication of previously identified associations between androgens, particularly testosterone-DHEA, and with developmental measures suggests hair may offer a valid method of hormone measurement for DHEA and testosterone.

摘要

激素分析是理解生理和行为相互作用的一种有价值的工具。头发中的皮质醇最近被作为衡量长期激素分泌的指标进行了研究。本研究旨在探讨头发中其他雄激素与人体测量指标之间的关系。在一个儿童样本(n=114,平均年龄:8.5 岁,66 名女性)中,在距头皮近端 0-3cm 处检测到皮质醇、脱氢表雄酮(DHEA)和睾酮的水平。对女性参与者的一个子样本(n=35)的 3-6cm 段进行了检查和比较。结果表明,睾酮与 DHEA 呈强相关,与皮质醇(仅 0-3cm)呈中度相关。在 3-6cm 段中存在更高的激素浓度。最后,DHEA 与身高呈弱正相关。雄激素之间先前确定的关联,特别是睾酮-DHEA,以及与发育指标的关联的复制表明,头发可能是 DHEA 和睾酮的有效激素测量方法。

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