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本文引用的文献

1
Association of Traditional Cardiovascular Risk Factors With Venous Thromboembolism: An Individual Participant Data Meta-Analysis of Prospective Studies.传统心血管危险因素与静脉血栓栓塞的关联：前瞻性研究的个体参与者数据荟萃分析
Circulation. 2017 Jan 3;135(1):7-16. doi: 10.1161/CIRCULATIONAHA.116.024507. Epub 2016 Nov 9.
2
Is diabetes mellitus a risk factor for venous thromboembolism? A systematic review and meta-analysis of case-control and cohort studies.糖尿病是静脉血栓栓塞的危险因素吗？病例对照研究和队列研究的系统评价与荟萃分析。
Eur J Intern Med. 2016 Mar;28:52-8. doi: 10.1016/j.ejim.2015.10.001. Epub 2015 Oct 23.
3
Genetic variations associated with recurrent venous thrombosis.与复发性静脉血栓形成相关的基因变异
Circ Cardiovasc Genet. 2014 Dec;7(6):806-13. doi: 10.1161/CIRCGENETICS.114.000682. Epub 2014 Sep 10.
4
Hyperglycemia, assessed according to HbA1c , and future risk of venous thromboembolism: the Tromsø study.根据 HbA1c 评估的高血糖与静脉血栓栓塞的未来风险：特罗姆瑟研究。
J Thromb Haemost. 2014;12(3):313-9. doi: 10.1111/jth.12498.
5
Glycemia (hemoglobin A1c) and incident venous thromboembolism in the Atherosclerosis Risk in Communities cohort study.血糖（糖化血红蛋白 A1c）与社区动脉粥样硬化风险研究中静脉血栓栓塞事件的关系。
Vasc Med. 2013 Oct;18(5):245-50. doi: 10.1177/1358863X13506764.
6
Relationship between venous and arterial thrombosis: a review of the literature from a causal perspective.静脉血栓与动脉血栓的关系：从因果角度对文献的综述。
Semin Thromb Hemost. 2011 Nov;37(8):885-96. doi: 10.1055/s-0031-1297367. Epub 2011 Dec 23.
7
Stress-induced hyperglycaemia and venous thromboembolism following total hip or total knee arthroplasty: analysis from the RECORD trials.应激性高血糖与全髋关节或全膝关节置换术后静脉血栓栓塞：来自 RECORD 试验的分析。
Thromb Haemost. 2012 Feb;107(2):225-31. doi: 10.1160/TH11-07-0447. Epub 2011 Dec 21.
8
High levels of glucose at time of diagnosing venous thrombosis: a case-control study.
J Thromb Haemost. 2011 Apr;9(4):883-5. doi: 10.1111/j.1538-7836.2011.04226.x.
9
Is diabetes mellitus an independent risk factor for venous thromboembolism?: a population-based case-control study.糖尿病是静脉血栓栓塞的独立危险因素吗？：一项基于人群的病例对照研究。
Arterioscler Thromb Vasc Biol. 2009 Sep;29(9):1399-405. doi: 10.1161/ATVBAHA.109.189290. Epub 2009 Jun 18.
10
Venous thrombosis is associated with hyperglycemia at diagnosis: a case-control study.
J Thromb Haemost. 2009 Jun;7(6):945-9. doi: 10.1111/j.1538-7836.2009.03442.x. Epub 2009 May 4.

血糖水平和糖尿病与静脉血栓形成的风险无关：来自 MEGA 病例对照研究的结果。

Glucose levels and diabetes are not associated with the risk of venous thrombosis: results from the MEGA case-control study.

机构信息

Department of Clinical Epidemiology, Leiden University Medical Centre, Leiden, the Netherlands.

Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Centre, Leiden, the Netherlands.

出版信息

Br J Haematol. 2019 Feb;184(3):431-435. doi: 10.1111/bjh.15599. Epub 2018 Nov 27.

DOI:10.1111/bjh.15599
PMID:30478992
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6587875/
Abstract

It is unclear whether hyperglycaemia or diabetes mellitus are risk factors for a first venous thrombosis (VT). Self-reported diabetes status and fasting glucose (FG) measures were collected from the Multiple Environmental and Genetic Assessment (MEGA) study to confirm these associations. FG levels were categorized based on the World Health Organization criteria [<6·1 (reference), 6·1-7·0 (2nd), ≥7·0 (3rd) mmol/l]. Logistic regression was performed to quantify the associations. Neither increased FG levels [Odds ratio (95% confidence interval): 0·98 (0·69-1·37) 2nd vs. reference, 0·97 (0·58-1·63) 3rd vs. reference] nor self-reported diabetes [1·12 (0·80-1·58)] were associated with an increased risk of a first VT.

摘要

高血糖或糖尿病是否是首次静脉血栓形成（VT）的危险因素尚不清楚。通过多发性环境和遗传评估（MEGA）研究收集了自我报告的糖尿病状况和空腹血糖（FG）测量值，以确认这些关联。FG 水平根据世界卫生组织标准进行分类[<6·1（参考）、6·1-7·0（第 2 类）、≥7·0（第 3 类）mmol/L]。使用逻辑回归来量化关联。无论是升高的 FG 水平[比值比（95%置信区间）：0·98（0·69-1·37）第 2 类与参考值相比，0·97（0·58-1·63）第 3 类与参考值相比]还是自我报告的糖尿病[1·12（0·80-1·58)]与首次 VT 风险增加无关。