血糖水平和糖尿病与静脉血栓形成的风险无关：来自 MEGA 病例对照研究的结果。
Glucose levels and diabetes are not associated with the risk of venous thrombosis: results from the MEGA case-control study.
机构信息
Department of Clinical Epidemiology, Leiden University Medical Centre, Leiden, the Netherlands.
Einthoven Laboratory for Experimental Vascular Medicine, Leiden University Medical Centre, Leiden, the Netherlands.
出版信息
Br J Haematol. 2019 Feb;184(3):431-435. doi: 10.1111/bjh.15599. Epub 2018 Nov 27.
Abstract
It is unclear whether hyperglycaemia or diabetes mellitus are risk factors for a first venous thrombosis (VT). Self-reported diabetes status and fasting glucose (FG) measures were collected from the Multiple Environmental and Genetic Assessment (MEGA) study to confirm these associations. FG levels were categorized based on the World Health Organization criteria [<6·1 (reference), 6·1-7·0 (2nd), ≥7·0 (3rd) mmol/l]. Logistic regression was performed to quantify the associations. Neither increased FG levels [Odds ratio (95% confidence interval): 0·98 (0·69-1·37) 2nd vs. reference, 0·97 (0·58-1·63) 3rd vs. reference] nor self-reported diabetes [1·12 (0·80-1·58)] were associated with an increased risk of a first VT.
摘要
高血糖或糖尿病是否是首次静脉血栓形成（VT）的危险因素尚不清楚。通过多发性环境和遗传评估（MEGA）研究收集了自我报告的糖尿病状况和空腹血糖（FG）测量值，以确认这些关联。FG 水平根据世界卫生组织标准进行分类[<6·1（参考）、6·1-7·0（第 2 类）、≥7·0（第 3 类）mmol/L]。使用逻辑回归来量化关联。无论是升高的 FG 水平[比值比（95%置信区间）：0·98（0·69-1·37）第 2 类与参考值相比，0·97（0·58-1·63）第 3 类与参考值相比]还是自我报告的糖尿病[1·12（0·80-1·58)]与首次 VT 风险增加无关。
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