Eslami Yadollah, Vahedian Zakieh, Moghimi Sasan, Bazvand Fatemeh, Salari Haniyeh, Shahabinejad Mojtaba, Malekpoor Afsaneh, Fakhraie Ghasem
Department of Ophthalmology, Glaucoma Service, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Department of Ophthalmology, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran.
J Ophthalmic Vis Res. 2018 Oct-Dec;13(4):453-457. doi: 10.4103/jovr.jovr_186_17.
This study aimed to measure the peripapillary retinal nerve fiber layer (RNFL) thickness using spectral-domain optical coherence tomography (SD-OCT) in normal Iranian children aged below 18 years.
Peripapillary RNFL imaging was performed in the right eye of normal Iranian children aged below 18 years using Spectralis SD-OCT (Heidelberg Engineering; Vista, CA). The effects of age, gender, cup-to-disc ratio, and spherical equivalent (SE) on global and sectoral RNFL thicknesses were evaluated.
A total of 115 eyes were imaged. Approximately 51 (44.3%) of the cases were female children. The mean age was 12.44 ± 2.52 years. The SE of refractive error was 0.39 ± 1.38 diopters (range: -3.00 to +4.5 D). The RNFL thickness measurements in the superior, inferior, nasal, and temporal quadrants were 129.25 ± 14.52, 128.16 ± 13.46, 76.76 ± 10.58, and 69.58 ± 9.94 μm, respectively. The global RNFL thickness was 101.01 ± 7.74 μm. In both univariate and multiple regression analyses, SE was the only determinant of RNFL thickness (all values < 0.05).
OCT analysis can effectively measure RNFL thickness in children, and SE is the only determinant of RNFL thickness in normal Iranian patients aged below 18 years.
本研究旨在使用光谱域光学相干断层扫描（SD - OCT）测量18岁以下伊朗正常儿童的视乳头周围视网膜神经纤维层（RNFL）厚度。
使用Spectralis SD - OCT（海德堡工程公司；加利福尼亚州维斯塔）对18岁以下伊朗正常儿童的右眼进行视乳头周围RNFL成像。评估年龄、性别、杯盘比和等效球镜度（SE）对整体和扇形RNFL厚度的影响。
共对115只眼睛进行了成像。约51例（44.3%）为女童。平均年龄为12.44±2.52岁。屈光不正的SE为0.39±1.38屈光度（范围：-3.00至+4.5 D）。上、下、鼻侧和颞侧象限的RNFL厚度测量值分别为129.25±14.52、128.16±13.46、76.76±10.58和69.58±9.94μm。整体RNFL厚度为101.01±7.74μm。在单变量和多变量回归分析中，SE是RNFL厚度的唯一决定因素（所有P值<0.05）。
OCT分析可有效测量儿童的RNFL厚度，且SE是18岁以下伊朗正常患者RNFL厚度的唯一决定因素。
