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查尔森合并症指数可预测接受手术治疗的髋部骨折患者的5年生存率。

Charlson Comorbidity Index Predicts 5-Year Survivorship of Surgically Treated Hip Fracture Patients.

作者信息

Jiang Lei, Chou Andrew Chia Chen, Nadkarni Nivedita, Ng Caris En Qi, Chong Yun San, Howe Tet Sen, Koh Joyce Suang Bee

机构信息

Department of Orthopaedic Surgery, Singapore General Hospital, Singapore, Singapore.

Centre for Quantitative Medicine, Duke-NUS Medical School, Singapore, Singapore.

出版信息

Geriatr Orthop Surg Rehabil. 2018 Nov 21;9:2151459318806442. doi: 10.1177/2151459318806442. eCollection 2018.

Abstract

INTRODUCTION

This study aims to assess the correlation of the age-adjusted Charlson comorbidity index (ACCI) with 5-year mortality in a surgically treated hip fracture population.

MATERIALS AND METHODS

A retrospective analysis was performed on 1057 patients aged 60 years and above who underwent surgery for hip fracture with a minimum of 5-year follow-up (92.2% 5-year follow-up rate) in a tertiary hospital. Manual review of patients' electronic hospital records was performed to record demographic data, comorbidities, and length of stay. Mortality data were extracted from the hospital's electronic medical records and corroborated with the National Electronic Health Record.

RESULTS

Of the 1057 patients, 283 (26.8%) were male. The majority of patients were 80 years of age and above (42.5%), with the oldest patient operated on age 102 with a mean age of 77.8 (8.6) years. Four hundred eighteen (39.5%) patients sustained extracapsular intertrochanteric fractures. The mean follow-up duration was 8 years and 3 days with an overall survivorship of 37.2%. A multiple regression model constructed with ACCI, age, gender, and fracture pattern demonstrated satisfactory predictive ability with a concordance statistic of 0.68. Patients with a higher ACCI category (≥6) had an increased 5-year mortality rate (41.8%) with an odds ratio of 13.6 (6.7-31.8, < .001) compared to those with an ACCI category of 3 and below (89.3%).

DISCUSSION

The study demonstrates that ACCI correlated with 5-year mortality after surgical treatment of hip fracture. This information is pertinent in the counseling of patients with regard to their midterm survival following hip fracture surgery and may inform policy makers of the varied midterm survival rates in patients with differing ACCI scores and educate the allocation of health-care resources.

CONCLUSION

The ACCI correlates with 5-year mortality after surgical treatment of hip fracture.

摘要

引言

本研究旨在评估年龄校正的查尔森合并症指数(ACCI)与接受手术治疗的髋部骨折患者5年死亡率之间的相关性。

材料与方法

对一家三级医院中1057例60岁及以上接受髋部骨折手术且至少随访5年(随访率为92.2%)的患者进行回顾性分析。人工查阅患者的电子病历,记录人口统计学数据、合并症及住院时间。从医院电子病历中提取死亡率数据,并与国家电子健康记录进行核对。

结果

1057例患者中,283例(26.8%)为男性。大多数患者年龄在80岁及以上(42.5%),年龄最大的患者为102岁,平均年龄为77.8(8.6)岁。418例(39.5%)患者发生囊外转子间骨折。平均随访时间为8年零3天,总体生存率为37.2%。用ACCI、年龄、性别和骨折类型构建的多元回归模型显示出良好的预测能力,一致性统计量为0.68。与ACCI类别为3及以下的患者(89.3%)相比,ACCI类别较高(≥6)的患者5年死亡率增加(41.8%),优势比为13.6(6.7 - 31.8,P <.001)。

讨论

该研究表明,ACCI与髋部骨折手术治疗后的5年死亡率相关。这一信息对于向患者咨询髋部骨折手术后的中期生存情况具有重要意义,并且可能使政策制定者了解不同ACCI评分患者的不同中期生存率,并为卫生保健资源的分配提供参考。

结论

ACCI与髋部骨折手术治疗后的5年死亡率相关。

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