Aging Research Center, Karolinska Institutet, Gävlegatan 16, 11330 Stockholm, Sweden.
Neurobiol Aging. 2010 Nov;31(11):1927-36. doi: 10.1016/j.neurobiolaging.2008.10.007. Epub 2008 Dec 5.
Physical activity has been associated with decreased dementia risk in recent studies, but the effects for structural brain changes (i.e. white matter lesions (WML) and/or brain atrophy) have remained unclear. The CAIDE participants were a random population-based sample studied in midlife and re-examined on average 21 years later (n=2000). A subpopulation (n=75; 31 control, 23 MCI, 21 dementia) was MRI scanned at the re-examination. T1-weighted images were used to investigate grey matter (GM) density, and FLAIR-images for WML rating. Persons who actively participated in physical activity at midlife tended to have larger total brain volume (β 0.12; 95% CI 0.17-1.16, p=0.10) in late-life than sedentary persons even after adjustments. GM volume was larger among the active (β 0.19; 95% CI 0.07-1.48, p=0.03), whereas the association between midlife physical activity and larger WM volume became non-significant (β 0.03; 95% CI -0.64 to 0.86, p=0.77) after full adjustments. The differences in the GM density localized mainly in frontal lobes. There was no significant association between midlife physical activity and severe WML later in life after full adjustments (OR 4.20, 95% CI 0.26-69.13, p=0.32).
在最近的研究中，身体活动与痴呆风险降低有关，但对结构脑变化（即白质病变（WML）和/或脑萎缩）的影响仍不清楚。CAIDE 参与者是一项在中年进行的随机人群基础研究，并在平均 21 年后重新检查（n=2000）。一个亚组（n=75；31 名对照，23 名 MCI，21 名痴呆）在重新检查时进行了 MRI 扫描。T1 加权图像用于研究灰质（GM）密度，FLAIR 图像用于 WML 评分。在中年积极参加身体活动的人在晚年的大脑总容量（β 0.12；95%置信区间 0.17-1.16，p=0.10）比久坐的人更大，即使经过调整也是如此。在活跃人群中 GM 体积更大（β 0.19；95%置信区间 0.07-1.48，p=0.03），而中年身体活动与更大的 WM 体积之间的关联在完全调整后变得不显著（β 0.03；95%置信区间 -0.64 至 0.86，p=0.77）。GM 密度的差异主要位于额叶。在完全调整后，中年身体活动与晚年严重 WML 之间没有显著关联（OR 4.20，95%置信区间 0.26-69.13，p=0.32）。
