Trudinger B J, Cook C M, Thompson R S, Giles W B, Connelly A
Department of Obstetrics and Gynaecology, University of Sydney, Westmead Hospital, New South Wales, Australia.
Am J Obstet Gynecol. 1988 Sep;159(3):681-5. doi: 10.1016/s0002-9378(88)80034-6.
A randomized, placebo-controlled, double-blind trial was carried out to evaluate the fetal benefits of low-dose aspirin (150 mg/day) as a treatment of placental insufficiency during the last trimester of pregnancy. Forty-six women referred for study because there was concern about fetal welfare were found to have an elevated umbilical artery wave form systolic/diastolic ratio. Mothers with severe hypertension were excluded because fetal condition would not necessarily be the dominant determinant of obstetric decision making. A distinction was made between a high systolic/diastolic ratio (greater than 95th but less than 99.95th percentile) and an extreme systolic/diastolic ratio (greater than 99.95th percentile). There were 34 patients in the high ratio group and 12 in the extreme group. Aspirin therapy was associated with an increase in birth weight (mean difference 526 gm [p less than 0.02]), head circumference (1.7 cm [p less than 0.025]), and placental weight (136 gm [p less than 0.02]) in those patients with a high initial umbilical artery systolic/diastolic ratio. For the 12 women with an extreme initial systolic/diastolic ratio, aspirin therapy did not result in a significantly different pregnancy outcome.
进行了一项随机、安慰剂对照、双盲试验，以评估低剂量阿司匹林（150毫克/天）作为妊娠晚期胎盘功能不全治疗方法对胎儿的益处。46名因担心胎儿健康而被转诊进行研究的女性被发现脐动脉波形收缩压/舒张压比值升高。患有严重高血压的母亲被排除在外，因为胎儿状况不一定是产科决策的主要决定因素。高收缩压/舒张压比值（大于第95百分位数但小于第99.95百分位数）和极高收缩压/舒张压比值（大于第99.95百分位数）之间存在区别。高比值组有34名患者，极高组有12名患者。对于初始脐动脉收缩压/舒张压比值高的患者，阿司匹林治疗与出生体重增加（平均差异526克[p<0.02]）、头围增加（1.7厘米[p<0.025]）和胎盘重量增加（136克[p<0.02]）相关。对于12名初始收缩压/舒张压比值极高的女性，阿司匹林治疗并未导致明显不同的妊娠结局。
