Ragin Camille, Banydeen Rishika, Zhang Christine, Ben Athena, Calabrese Victoria, Villa Nina N, Reville Jade, Dasgupta Shaoni, Bandyopadhyay Mausumi, Louden Delroy, Dasgupta Subhajit
Camille Ragin, Fox Chase Cancer Center, Temple Health; Camille Ragin, African Caribbean Cancer Consortium, Philadelphia, PA; Rishika Banydeen, Centre Hospitalier Universitaire de Martinique; Rishika Banydeen, African Caribbean Cancer Consortium, Fort-de-France, Martinique; Christine Zhang, Athena Ben, Victoria Calabrese, Nina N. Villa, Jade Reville, and Subhajit Dasgupta, Saint James School of Medicine; Subhajit Dasgupta, African Caribbean Cancer Consortium, The Quarter; Delroy Louden, Anguilla Community College, George Hill, Anguilla; Shaoni Dasgupta, Academic Magnet High School; and Mausumi Bandyopadhyay, Trident Technical College, Charleston, SC.
J Glob Oncol. 2018 Nov;4:1-21. doi: 10.1200/JGO.18.00044.
Breast cancer is among the leading causes of death resulting from cancer in Caribbean women. Studies examining exogenous and genetically predetermined endogenous risk factors are critical to define breast cancer susceptibility in Caribbean women. The purpose of this systematic review is to assess the existing scientific literature in the last 42 years (1975 to 2017) to describe the body of research generated for the population of this region and determine future research directions.
We selected published research articles using a combination of definite keyword searches in PubMed. Only articles presenting the Caribbean population as the focus of their research objectives were included in this analysis.
Studies on breast cancer in the Caribbean are limited. A majority of publications on Caribbean populations were descriptive, focusing on cancer trends and clinicopathologic factors. High incidence and mortality rates for breast cancer are reported for the region, and there seem to be some differences between countries in the frequency of cases according to age at presentation. A limited number of epidemiologic, behavioral, and genetic and molecular studies were conducted in more recent years.
A regional strategy for cancer registration is needed for the Caribbean to address possible underestimates of breast cancer incidence. Furthermore, behavioral, molecular, genetic, and epidemiologic investigations of breast cancer are critical to address the concerns related to currently described high incidence and mortality rates in the Caribbean.
乳腺癌是加勒比地区女性癌症死亡的主要原因之一。研究外源性和基因预定的内源性风险因素对于确定加勒比地区女性的乳腺癌易感性至关重要。本系统评价的目的是评估过去42年（1975年至2017年）的现有科学文献，以描述针对该地区人群开展的研究情况，并确定未来的研究方向。
我们在PubMed中使用特定关键词搜索组合来选择已发表的研究文章。本分析仅纳入将加勒比地区人群作为研究目标重点的文章。
加勒比地区关于乳腺癌的研究有限。大多数关于加勒比地区人群的出版物都是描述性的，重点关注癌症趋势和临床病理因素。该地区报告了较高的乳腺癌发病率和死亡率，而且不同国家之间在发病年龄的病例频率方面似乎存在一些差异。近年来开展的流行病学、行为学以及基因和分子研究数量有限。
加勒比地区需要一项癌症登记区域战略，以应对可能存在的乳腺癌发病率低估问题。此外，对乳腺癌进行行为学、分子学、遗传学和流行病学调查对于解决加勒比地区目前所描述的高发病率和高死亡率相关问题至关重要。
