Departamento de Psicobiología y Metodología de las Ciencias del Comportamiento, Instituto de Investigación Biomédica de Málaga (IBIMA), Facultad de Psicología, Universidad de Málaga, Spain.
Departamento de Psicobiología y Metodología de las Ciencias del Comportamiento, Instituto de Investigación Biomédica de Málaga (IBIMA), Facultad de Psicología, Universidad de Málaga, Spain.
Neurosci Biobehav Rev. 2019 Nov;106:23-48. doi: 10.1016/j.neubiorev.2018.11.015. Epub 2018 Nov 24.
Drug addiction is a chronic and relapsing disorder in which repeated drug exposure compromises brain neuroplasticity. Brain areas normally involved in learning and goal-directed behaviors become corrupted, which may lead to cognitive deficits that coexist with other addiction symptoms and predict a worse treatment outcome. New learning experiences that are not motivated by drugs may improve both cognitive deficits and drug-induced symptoms by promoting adaptive neuroplastic changes that could alleviate or reverse those involved in addiction. The present review will focus on whether potentiating healthy cognitive function, either by formal cognitive training or non-drug related environmental experiences, could exert beneficial effects in the therapeutics of addiction. Although additional studies are needed, the available clinical and preclinical evidence suggests that cognitive stimulation may provide a valuable adjuvant intervention in drug addiction.
药物成瘾是一种慢性和复发性疾病，其中反复的药物暴露会损害大脑的神经可塑性。正常参与学习和目标导向行为的大脑区域受到影响，这可能导致认知缺陷，这些缺陷与其他成瘾症状并存，并预测治疗结果更差。新的学习经验，如果不是由药物驱动的，可能通过促进适应性神经可塑性变化来改善认知缺陷和药物引起的症状，这些变化可能减轻或逆转与成瘾相关的变化。本综述将集中讨论通过正式的认知训练或与药物无关的环境经验来增强健康的认知功能是否能对成瘾的治疗产生有益的影响。尽管还需要更多的研究，但现有的临床和临床前证据表明，认知刺激可能为药物成瘾提供一种有价值的辅助干预措施。
Zotero 插件