来吧，甜蜜的死亡：靶向糖体蛋白导入用于抗锥虫药物开发。

Come, sweet death: targeting glycosomal protein import for antitrypanosomal drug development.

机构信息

Institute of Biochemistry and Pathobiochemistry, Department of Systems Biochemistry, Faculty of Medicine, Ruhr University Bochum, 44780 Bochum, Germany.

Swiss Tropical and Public Health Institute, Socinstrasse 57, 4051 Basel, Switzerland; University of Basel, 4001 Basel, Switzerland.

出版信息

Curr Opin Microbiol. 2018 Dec;46:116-122. doi: 10.1016/j.mib.2018.11.003. Epub 2018 Nov 24.

DOI:10.1016/j.mib.2018.11.003

PMID:30481613

Abstract

Glycosomes evolved as specialized system for glycolysis in trypanosomatids. These organelle rely on protein import to maintain function. A machinery of peroxin (PEX) proteins is responsible for recognition and transport of glycosomal proteins to the organelle. Disruption of PEX-based import system was expected to be a strategy against trypanosomatids. Recently, a proof of this hypothesis has been presented. Here, we review current information about trypanosomatids' glycosomal transport components as targets for new trypanocidal therapies.

摘要

糖体是原生动物为糖解作用而进化出的一种特殊系统。这些细胞器依赖于蛋白质的输入来维持其功能。过氧化物酶体（PEX）蛋白的机制负责识别和运输糖体蛋白到细胞器。破坏基于 PEX 的输入系统预计将成为对抗原生动物的一种策略。最近，这一假设得到了验证。在这里，我们回顾了关于原生动物糖体转运成分作为新的杀锥虫治疗靶点的最新信息。