Yang X R, Sun J, Wang J, Lu Y Y
Comprehensive Liver Cancer Center, 302 Military Hospital of Chinese Army, Beijing 100039, China.
Beijing Institute of Basic Medical Sciences, Beijing 100850, China.
Zhonghua Gan Zang Bing Za Zhi. 2018 Sep 20;26(9):714-717. doi: 10.3760/cma.j.issn.1007-3418.2018.09.019.
Liver cancer is one of the most common malignant tumors in China, ranking fifth in malignant tumors and the third in tumor-related deaths. As a membrane-related protein, the asymmetric distribution of cell fate determinant Numb plays a key role in cell differentiation. Research reports that Numb may be closely associated to the occurrence and development of tumors. Recently, scholars have gradually valued its important role in liver cancer. This article briefly reviews the structure of Numb molecule, relationship between Numb and tumorigenesis, the molecular mechanism of Numb-regulated tumors, and the role of Numb in the development of liver cancer.
肝癌是中国最常见的恶性肿瘤之一，在恶性肿瘤中排名第五，在肿瘤相关死亡中排名第三。作为一种膜相关蛋白，细胞命运决定因子Numb的不对称分布在细胞分化中起关键作用。研究报道Numb可能与肿瘤的发生发展密切相关。近年来，学者们逐渐重视其在肝癌中的重要作用。本文简要综述了Numb分子的结构、Numb与肿瘤发生的关系、Numb调控肿瘤的分子机制以及Numb在肝癌发生发展中的作用。
