多功能蛋白：探索 NUMB 的多种功能
The Multitasker Protein: A Look at the Multiple Capabilities of NUMB.
机构信息
Instituto de Biomedicina de Sevilla (IBIS), Hospital Universitario Virgen del Rocío (HUVR), Consejo Superior de Investigaciones Científicas, Universidad de Sevilla, 41013 Sevilla, Spain.
CIBERONC, Instituto de Salud Carlos III, 28029 Madrid, Spain.
出版信息
Cells. 2023 Jan 15;12(2):333. doi: 10.3390/cells12020333.
NUMB, a plasma membrane-associated protein originally described in , is involved in determining cell function and fate during early stages of development. It is secreted asymmetrically in dividing cells, with one daughter cell inheriting NUMB and the other inheriting its antagonist, NOTCH. NUMB has been proposed as a polarizing agent and has multiple functions, including endocytosis and serving as an adaptor in various cellular pathways such as NOTCH, Hedgehog, and the P53-MDM2 axis. Due to its role in maintaining cellular homeostasis, it has been suggested that NUMB may be involved in various human pathologies such as cancer and Alzheimer's disease. Further research on NUMB could aid in understanding disease mechanisms and advancing the field of personalized medicine and the development of new therapies.
NUMB 是一种最初在 中描述的质膜相关蛋白，参与在发育早期确定细胞功能和命运。它在分裂细胞中不对称地分泌，一个子细胞继承 NUMB，另一个子细胞继承其拮抗剂 NOTCH。NUMB 被提议作为一种极化剂，具有多种功能，包括内吞作用，并作为各种细胞途径中的衔接物，如 NOTCH、Hedgehog 和 P53-MDM2 轴。由于其在维持细胞内稳态中的作用，NUMB 可能参与各种人类疾病，如癌症和阿尔茨海默病。对 NUMB 的进一步研究可以帮助理解疾病机制，推进个性化医学领域的发展，并开发新的治疗方法。
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