Ennis F A, Martin W J, Verbonitz M W
Dev Biol Stand. 1977;39:373-8.
Cytotoxic thymus derived (T) lymphocytes were readily detected in BALB/c and C3H mice during infection with influenza A (H0N1, H3N2, Heq1Neq1) and B viruses. T cell mediated lysis was specific for H-2 compatible target cells infected with the same strain of virus used to immunize the mice. The viral specificity was found to be related to the hemagglutinin antigen by the use of parent strains (H3N2 and HeqNeq) and their recombinant viruses which included the antigenic hybrids for hemagglutinin and neuraminidase (H3Neq1 and Heq1n2). In addition, cytotoxic T cell mediated lysis of influenza infected cells was demonstrated to be restricted to syngeneic cells and cells sharing the same H-2 haplotype. Thus, T cell mediated lysis of influenza infected cells appears to involve the distinct recognition of viral and H-2 antigens on the infected cell by the cytotoxic T cell.
在感染甲型流感（H0N1、H3N2、Heq1Neq1）和乙型流感病毒期间，很容易在BALB/c和C3H小鼠中检测到细胞毒性胸腺来源的（T）淋巴细胞。T细胞介导的裂解作用对感染了用于免疫小鼠的同株病毒的H-2相容靶细胞具有特异性。通过使用亲本毒株（H3N2和HeqNeq）及其重组病毒（包括血凝素和神经氨酸酶的抗原杂种，即H3Neq1和Heq1n2），发现病毒特异性与血凝素抗原有关。此外，细胞毒性T细胞介导的流感感染细胞的裂解作用被证明仅限于同基因细胞和共享相同H-2单倍型的细胞。因此，T细胞介导的流感感染细胞的裂解作用似乎涉及细胞毒性T细胞对感染细胞上病毒和H-2抗原的独特识别。
